Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol

Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that several specific actions of alcohol (ethanol) are mediated by the neurosteroid 3α-hydroxy-5α-pregnan-20-one (3α,5α-T...

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Veröffentlicht in:The Journal of neuroscience 2000-03, Vol.20 (5), p.1982-1989
Hauptverfasser: VanDoren, Margaret J., Matthews, Douglas B., Janis, Gregory C., Grobin, A. Chistina, Devaud, Leslie L., Morrow, A. Leslie
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Sprache:eng
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