Mechanism of Interleukin-1- and Tumor Necrosis Factor α-Dependent Regulation of the α1-Antichymotrypsin Gene in Human Astrocytes

The expression of α 1 -antichymotrypsin (ACT) is significantly enhanced in affected brain regions in Alzheimer's disease. This serine proteinase inhibitor specifically colocalizes with filamentous β-amyloid deposits and recently has been shown to influence both formation and destabilization of...

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Veröffentlicht in:	The Journal of neuroscience 2000-10, Vol.20 (20), p.7510-7516
Hauptverfasser:	Kordula, Tomasz, Bugno, Marcin, Rydel, Russell E., Travis, James
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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