Vascular Endothelial Cell Growth Factors Promote the In Vitro Development of Rat Photoreceptor Cells

We have identified and characterized a novel trophic effect of vascular endothelial cell growth factor (VEGF) on photoreceptor cells. Treatment of retinal cultures, derived from postnatal day 1 (P1) rats, with VEGF-2 resulted in a dose- and time-dependent increase in the level of rhodopsin protein,...

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Veröffentlicht in:	The Journal of neuroscience 2000-09, Vol.20 (18), p.6781-6788
Hauptverfasser:	Yourey, Pamela A, Gohari, Shiva, Su, Jeffery L, Alderson, Ralph F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Cell Count - drug effects Cell Differentiation - drug effects Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Ciliary Neurotrophic Factor - pharmacology Dose-Response Relationship, Drug Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - metabolism Endothelial Growth Factors - pharmacology Enzyme-Linked Immunosorbent Assay gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacokinetics Growth Substances - metabolism Growth Substances - pharmacology Lymphokines - antagonists & inhibitors Lymphokines - metabolism Lymphokines - pharmacology Photoreceptor Cells - cytology Photoreceptor Cells - drug effects Photoreceptor Cells - growth & development Photoreceptor Cells - metabolism Protein Isoforms - metabolism Protein Isoforms - pharmacology Rats Rats, Sprague-Dawley Retina - cytology Retina - drug effects Retina - embryology Rhodopsin - metabolism Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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