Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying mechanisms are unknown. We now report that homocysteine induces apoptosis in rat hippocampal neurons. DNA strand breaks and...

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Veröffentlicht in:	The Journal of neuroscience 2000-09, Vol.20 (18), p.6920-6926
Hauptverfasser:	Kruman, Inna I, Culmsee, Carsten, Chan, Sic L, Kruman, Yuri, Guo, Zhihong, Penix, LaRoy, Mattson, Mark P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Benzamides - pharmacology Calcium - metabolism Cells, Cultured DNA - drug effects DNA - metabolism DNA Damage Egtazic Acid - analogs & derivatives Enzyme Inhibitors - pharmacology Excitatory Amino Acid Agonists - pharmacology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism homocysteine Homocysteine - metabolism Homocysteine - pharmacology Intracellular Fluid - metabolism Kainic Acid - pharmacology Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism NAD - metabolism Neurons - cytology Neurons - drug effects Neurons - metabolism peroxisome proliferator-activated receptor ^g Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Rats Tumor Suppressor Protein p53 - metabolism
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