NGF Signals through TrkA to Increase Clathrin at the Plasma Membrane and Enhance Clathrin-Mediated Membrane Trafficking

Neurotrophin (NT) signals may be moved from axon terminals to neuron cell bodies via signaling endosomes-organelles in which NTs continue to be bound to their activated receptors. Suggesting that clathrin-coated membranes serve as one source of signaling endosomes, in earlier studies we showed that...

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Veröffentlicht in:	The Journal of neuroscience 2000-10, Vol.20 (19), p.7325-7333
Hauptverfasser:	Beattie, Eric C, Howe, Charles L, Wilde, Andrew, Brodsky, Frances M, Mobley, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 2 Adaptor Protein Complex alpha Subunits Adaptor Proteins, Vesicular Transport Animals Brain-Derived Neurotrophic Factor - metabolism Brain-Derived Neurotrophic Factor - pharmacology Cell Membrane - metabolism Cell Membrane - ultrastructure Cells, Cultured Clathrin - metabolism Clathrin Heavy Chains Endocytosis - drug effects Hippocampus - cytology Hippocampus - metabolism Humans Membrane Proteins - metabolism membrane trafficking Mice Nerve Growth Factor - metabolism Nerve Growth Factor - pharmacology Neurons - cytology Neurons - metabolism PC12 Cells Phosphorylation - drug effects Rats Rats, Sprague-Dawley Receptor, trkA - metabolism Signal Transduction - physiology
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