Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Deficiency Results in Exencephaly and Is Required for Apoptosis within the Developing CNS

Tumor necrosis factor receptor-associated factors (TRAFs) are adaptor proteins important in mediating intracellular signaling. We report here that targeted deletion of traf6 greatly increases the frequency of failure of neural tube closure and exencephaly in traf6 (-/-) mice. The penetrance of this...

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Veröffentlicht in:	The Journal of neuroscience 2000-10, Vol.20 (19), p.7384-7393
Hauptverfasser:	Lomaga, Mark A, Henderson, Jeffrey T, Elia, Andrew J, Robertson, Jennifer, Noyce, Ryan S, Yeh, Wen-Chen, Mak, Tak W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - biosynthesis Apoptosis - genetics Bromodeoxyuridine Cell Division - genetics Cell Movement - genetics Central Nervous System - metabolism Central Nervous System - pathology Genotype Heterozygote Homozygote Immunohistochemistry In Situ Nick-End Labeling Inbreeding Mice Mice, Inbred ICR Mice, Knockout Neural Tube Defects - genetics Neural Tube Defects - metabolism Neural Tube Defects - pathology Organ Specificity - genetics Penetrance Phenotype Proteins - genetics Proteins - metabolism Receptor, Nerve Growth Factor - metabolism TNF Receptor-Associated Factor 6 tumor necrosis factor receptor-associated factor 6
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