Protein Phosphatase-1 Regulation in the Induction of Long-Term Potentiation: Heterogeneous Molecular Mechanisms

Protein phosphatase inhibitor-1 (I-1) has been proposed as a regulatory element in the signal transduction cascade that couples postsynaptic calcium influx to long-term changes in synaptic strength. We have evaluated this model using mice lacking I-1. Recordings made in slices prepared from mutant a...

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Veröffentlicht in:	The Journal of neuroscience 2000-05, Vol.20 (10), p.3537-3543
Hauptverfasser:	Allen, Patrick B, Hvalby, Oivind, Jensen, Vidar, Errington, Michael L, Ramsay, Mark, Chaudhry, Farrukh A, Bliss, Timothy V. P, Storm-Mathisen, Jon, Morris, Richard G. M, Andersen, Per, Greengard, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins Dentate Gyrus - cytology Dentate Gyrus - physiology Excitatory Postsynaptic Potentials - physiology Female Gene Expression - physiology Intracellular Signaling Peptides and Proteins Long-Term Potentiation - genetics Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Mutant Strains Neuronal Plasticity - genetics Perforant Pathway - cytology Phosphoprotein Phosphatases - metabolism Phosphoproteins - metabolism Protein Phosphatase 1 Pyramidal Cells - chemistry Pyramidal Cells - enzymology RNA-Binding Proteins - analysis RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Space Perception - physiology Synapses - chemistry Synapses - enzymology Water
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