The Dopamine/D1 Receptor Mediates the Phosphorylation and Inactivation of the Protein Tyrosine Phosphatase STEP via a PKA-Dependent Pathway

The striatal-enriched protein tyrosine phosphatase (STEP) family is expressed within dopaminoceptive neurons of the CNS and is particularly enriched within the basal ganglia and related structures. Alternative splicing produces several isoforms that are found in a number of subcellular compartments,...

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Veröffentlicht in:	The Journal of neuroscience 2000-08, Vol.20 (15), p.5630-5638
Hauptverfasser:	Paul, Surojit, Snyder, Gretchen L, Yokakura, Hisayuki, Picciotto, Marina R, Nairn, Angus C, Lombroso, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Catalytic Domain Corpus Striatum - chemistry Corpus Striatum - cytology Corpus Striatum - enzymology Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation - physiology In Vitro Techniques Male Molecular Sequence Data Neurons - chemistry Neurons - enzymology Phosphoproteins - analysis Phosphorus Radioisotopes Phosphorylation Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - chemistry Protein Tyrosine Phosphatases - metabolism Protein Tyrosine Phosphatases, Non-Receptor Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - metabolism Signal Transduction - physiology
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