A metabolic profile of polyamines in parkinson disease: A promising biomarker

Objective Aging is the highest risk factor for Parkinson disease (PD). Under physiological conditions, spermidine and spermine experimentally enhance longevity via autophagy induction. Accordingly, we evaluated the ability of each polyamine metabolite to act as an age‐related, diagnostic, and severi...

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Veröffentlicht in:	Annals of neurology 2019-08, Vol.86 (2), p.251-263
Hauptverfasser:	Saiki, Shinji, Sasazawa, Yukiko, Fujimaki, Motoki, Kamagata, Koji, Kaga, Naoko, Taka, Hikari, Li, Yuanzhe, Souma, Sanae, Hatano, Taku, Imamichi, Yoko, Furuya, Norihiko, Mori, Akio, Oji, Yutaka, Ueno, Shin‐Ichi, Nojiri, Shuko, Miura, Yoshiki, Ueno, Takashi, Funayama, Manabu, Aoki, Shigeki, Hattori, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Alzheimer's disease Autophagy Biomarkers Biomarkers - blood Cell Line, Tumor Cell lines Cohort Studies Degeneration Diagnostic systems Female Genetic diversity Health risks Humans Magnetic resonance imaging Male Metabolism Metabolites Metabolome - physiology Middle Aged Movement disorders Neurodegeneration Neurodegenerative diseases Paralysis Parkinson Disease - blood Parkinson Disease - diagnostic imaging Parkinson's disease Phagocytosis Physiological effects Polyamines Polyamines - blood Progressive supranuclear palsy Risk analysis Risk factors Spermidine Spermine Tensors
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