Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity

MYC and RUNX oncogenes each trigger p53‐mediated failsafe responses when overexpressed in vitro and collaborate with p53 deficiency in vivo. However, together they drive rapid onset lymphoma without mutational loss of p53. This phenomenon was investigated further by transcriptomic analysis of premal...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-10, Vol.120 (10), p.18332-18345
Hauptverfasser:	Hay, Jodie, Gilroy, Kathryn, Huser, Camille, Kilbey, Anna, Mcdonald, Alma, MacCallum, Amanda, Holroyd, Ailsa, Cameron, Ewan, Neil, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding sites Blotting, Western Cbfa-1 protein CD28 antigen CD3 antigen CD30 antigen Cell death Cell Line, Tumor Cell Proliferation - genetics Cell Proliferation - physiology Cellular Senescence - genetics Cellular Senescence - physiology Collaboration Computational Biology Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Fibroblasts Functional analysis Genes Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Interleukin 1 Interleukin 13 Kinases Lymphoma Lymphoma - genetics Lymphoma - metabolism Mice Mice, Transgenic MYC Myc protein p53 p53 Protein Principal Component Analysis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism RUNX Senescence Signal Transduction - genetics Signal Transduction - physiology SMYD2 Thymus Thymus Gland - metabolism Transcription Transgenic mice Tumor cell lines Tumor Suppressor Protein p53
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