Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis

Objective Results from anti‐CD20 therapies demonstrate that B‐ and T‐cell interaction is a major driver of multiple sclerosis (MS). The local presence of B‐cell follicle‐like structures and oligoclonal bands in MS patients indicates that certain B cells infiltrate the central nervous system (CNS) to...

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Veröffentlicht in:	Annals of neurology 2019-08, Vol.86 (2), p.264-278
Hauptverfasser:	van Langelaar, Jamie, Rijvers, Liza, Janssen, Malou, Wierenga‐Wolf, Annet F., Melief, Marie‐José, Siepman, Theodora A., de Vries, Helga E., Unger, Peter‐Paul A., van Ham, S. Marieke, Hintzen, Rogier Q., van Luijn, Marvin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antigens B-Lymphocytes - metabolism Banded structure Blood Brain Brain - metabolism Brain - physiology CD20 antigen Cell differentiation Cell Movement - physiology Central nervous system Cerebrospinal fluid Chemokines CXC chemokines CXCR3 protein Differentiation (biology) Female Flow cytometry Gene Expression Humans Immunoglobulin G Interferon Lymphocytes B Male Mice Middle Aged Monoclonal antibodies Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Multiple Sclerosis - pathology NIH 3T3 Cells Receptors, CXCR3 - biosynthesis Receptors, CXCR3 - genetics TLR9 protein Toll-like receptors Young Adult γ-Interferon
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