Hydrogel increases diclofenac skin permeation and absorption

Purpose Topical nonsteroidal anti‐inflammatory drug formulations are used commonly to treat musculoskeletal pain and inflammation. Drug properties and formulation composition are the primary determinants of the transdermal drug delivery rate. The ex vivo transdermal flux through human skin of three...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2019-07, Vol.40 (7), p.217-224
Hauptverfasser:	Haltner‐Ukomadu, Eleonore, Sacha, Manuel, Richter, Andrea, Hussein, Khaled
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Diclofenac Diclofenac - administration & dosage Diffusion cells Drug delivery emulsion gel Female Formulations Gels High-performance liquid chromatography Humans hydrogel Hydrogels Hydrogels - administration & dosage In Vitro Techniques Inflammation Lipophilic Liquid chromatography Nonsteroidal anti-inflammatory drugs Original Paper Original Papers Pain Paraffin Permeability - drug effects Raman spectroscopy Skin Skin - drug effects Skin - metabolism Skin Absorption - drug effects Sodium Stratum corneum topical formulation transdermal Transdermal medication
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