Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming

Induction and reversal of chromatin silencing is critical for successful development, tissue homeostasis, and the derivation of induced pluripotent stem cells (iPSCs). X-Chromosome inactivation (XCI) and reactivation (XCR) in female cells represent chromosome-wide transitions between active and inac...

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Veröffentlicht in:	Genome research 2019-10, Vol.29 (10), p.1659-1672
Hauptverfasser:	Janiszewski, Adrian, Talon, Irene, Chappell, Joel, Collombet, Samuel, Song, Juan, De Geest, Natalie, To, San Kit, Bervoets, Greet, Marin-Bejar, Oskar, Provenzano, Caterina, Vanheer, Lotte, Marine, Jean-Christophe, Rambow, Florian, Pasque, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cellular Reprogramming - genetics Chromatin Chromatin - genetics Female Gene regulation Gene Silencing Genes Genes, X-Linked - genetics Histone Deacetylases - genetics Homeostasis Induced Pluripotent Stem Cells - cytology Intermediates Mice Pluripotency RNA, Long Noncoding - genetics Stem cell transplantation Stem cells Transcription activation Transcriptional Activation - genetics X Chromosome - genetics X Chromosome Inactivation - genetics X chromosomes X-chromosome inactivation
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