Effects of Macronutrients on the In Vitro Production of ClpB, a Bacterial Mimetic Protein of α-MSH and Its Possible Role in Satiety Signaling

Gut microbiota can influence the feeding behavior of the host, but the underlying mechanisms are unknown. Recently, caseinolytic protease B (ClpB), a disaggregation chaperon protein of , was identified as a conformational mimetic of α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropept...

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Veröffentlicht in:	Nutrients 2019-09, Vol.11 (9), p.2115
Hauptverfasser:	Dominique, Manon, Breton, Jonathan, Guérin, Charlène, Bole-Feysot, Christine, Lambert, Grégory, Déchelotte, Pierre, Fetissov, Sergueï
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation alpha-melanocyte-stimulating hormone Anaerobic conditions Animals Appetite Bacteria bovine serum albumin Carbohydrates cell culture Cells, Cultured ClpB protein Diet E coli Eating disorders Electrolytes Electrolytic cells Endopeptidase Clp - genetics Endopeptidase Clp - metabolism Escherichia coli Escherichia coli K12 - drug effects Escherichia coli K12 - enzymology Escherichia coli K12 - genetics Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fatty acids Feeding Behavior Food and Nutrition fructose Fructose - pharmacology Gastrointestinal Microbiome Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hormones Host-Pathogen Interactions Ingestion intestinal microorganisms intestinal mucosa Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Life Sciences Male Meals messenger RNA Metabolism Metabolites mice Microbiota Nutrients Obesity oleic acid Oleic Acid - pharmacology peptide YY Peptide YY - metabolism Peptides Physiological effects Physiology proteinases Proteins Psychopathology rats Rats, Sprague-Dawley Satiety Satiety Response Secretion Secretions Serum Albumin, Bovine - pharmacology Signal Transduction Stationary phase Weight control
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