More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous system, Sox2 is active in neural stem cells, and important for their self-renewal; differentiation to neurons and glia...

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Veröffentlicht in:	International journal of molecular sciences 2019-09, Vol.20 (18), p.4540
Hauptverfasser:	Mercurio, Sara, Serra, Linda, Nicolis, Silvia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Astrocytes Ataxia Basal ganglia Binding sites Cell adhesion & migration Cell Differentiation Cell Self Renewal Clonal deletion Defects Down-Regulation Embryogenesis Enhancers Epigenetics Forebrain Gene expression Genes Glial cells Hippocampus Humans Intellectual disabilities Mice Morphology Motor task performance Mutants Mutation Nervous system Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurodevelopmental disorders Neurogenesis Neuroglia - cytology Neuroglia - metabolism Neuronal-glial interactions Phenotypes Primordia Radial glial cells Review Roles Seizures Signal Transduction SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Stem cells Substantia alba Thyroid transcription factor 1 Transcription factors
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