Chemoradiation induces epithelial‐to‐mesenchymal transition in esophageal adenocarcinoma

Multimodality treatment has advanced the outcome of esophageal adenocarcinoma (EAC), but overall survival remains poor. Therapeutic pressure activates effective resistance mechanisms and we characterized these mechanisms in response to the currently used neoadjuvant treatment against EAC: carboplati...

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Veröffentlicht in:	International journal of cancer 2019-11, Vol.145 (10), p.2792-2803
Hauptverfasser:	Steins, Anne, Ebbing, Eva A., Creemers, Aafke, Zalm, Amber P., Jibodh, Rajni A., Waasdorp, Cynthia, Meijer, Sybren L., Delden, Otto M., Krishnadath, Kausilia K., Hulshof, Maarten C.C.M., Bennink, Roelof J., Punt, Cornelis J.A., Medema, Jan Paul, Bijlsma, Maarten F., Laarhoven, Hanneke W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - blood Adenocarcinoma - mortality Adenocarcinoma - therapy Adult Aged Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autocrine signalling biomarker Cancer Carboplatin Carboplatin - pharmacology Carboplatin - therapeutic use Cell Line, Tumor chemoradiation Chemoradiotherapy Chemoradiotherapy - methods Disease Progression Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - radiation effects Emission analysis Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - radiation effects epithelial‐to‐mesenchymal transition esophageal adenocarcinoma Esophageal cancer Esophageal Mucosa - diagnostic imaging Esophageal Mucosa - pathology Esophageal Neoplasms - blood Esophageal Neoplasms - mortality Esophageal Neoplasms - therapy Esophagectomy Esophagus Female Fluorodeoxyglucose F18 Health risks Humans Kaplan-Meier Estimate Lymph nodes Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Male Medical research Mesenchyme Metastases Metastasis Middle Aged Molecular Cancer Biology Neoadjuvant Therapy - methods Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Positron emission tomography Pressure Primary Cell Culture Progression-Free Survival Radiation therapy Serum levels Signal Transduction - drug effects Signal Transduction - radiation effects TGF‐β Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - blood Transforming Growth Factor beta - metabolism Transforming growth factor-b Treatment Outcome Xenograft Model Antitumor Assays
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