Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders
The male‐biased prevalence of certain neurodevelopmental disorders and the sex‐biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across ther...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2019-09, Vol.180 (6), p.390-414 |
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| creator | Tahira, Ana Carolina Barbosa, André Rocha Feltrin, Arthur Sant'Anna Gastaldi, Vinicius Daguano Toledo, Victor Hugo Calegari Carvalho Pereira, José Geraldo Lisboa, Bianca Cristina Garcia Souza Reis, Viviane Neri Santos, Ana Cecília Feio Maschietto, Mariana Brentani, Helena |
| description | The male‐biased prevalence of certain neurodevelopmental disorders and the sex‐biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP‐seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid‐gestation periods (FDR |
| doi_str_mv | 10.1002/ajmg.b.32704 |
| format | Article |
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Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP‐seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid‐gestation periods (FDR < 0.05), independent of sexual hormones. Genes with differential expression (24, p < 0.0001) and methylation (40, p < 0.047) between sexes were overrepresented in this set. Exclusive SOX3 or SRY target genes were more associated with the late gestational and postnatal periods. Using autism as a model sex‐biased disorder, the SOX3/SRY set was enriched in autism gene databases (FDR ≤ 0.05), and there were more de novo variations from the male autism spectrum disorder (ASD) samples under the SRY peaks compared to the random peaks (p < 0.024). The comparison of coexpressed networks of SOX3/SRY target genes between male autism and control samples revealed low preservation in gene modules related to stress response (99 genes) and neurogenesis (78 genes). This study provides evidence that while SOX3 is a regulatory mechanism for both sexes, the male‐exclusive SRY also plays a role in gene regulation, suggesting a potential mechanism for sex bias in ASD.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.32704</identifier><identifier>PMID: 30537354</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Autism ; Autism Spectrum Disorder - genetics ; Databases, Genetic ; DNA methylation ; DNA-Binding Proteins - genetics ; Female ; Gene Expression Regulation - genetics ; Gene regulation ; Gene Regulatory Networks ; Genes ; Genetic Predisposition to Disease ; Genetics ; Genomes ; Gestation ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; neurodevelopmental disorder ; Neurodevelopmental disorders ; Neurodevelopmental Disorders - genetics ; Neurogenesis ; Preservation ; Risk Factors ; sex ; Sex Chromosomes - genetics ; Sex Factors ; Sex hormones ; Sex-Determining Region Y Protein - genetics ; Sex-Determining Region Y Protein - metabolism ; Sexes ; SOX3 ; SOXB1 Transcription Factors - genetics ; SOXB1 Transcription Factors - metabolism ; SRY ; stress ; Transcription Factors - genetics</subject><ispartof>American journal of medical genetics. Part B, Neuropsychiatric genetics, 2019-09, Vol.180 (6), p.390-414</ispartof><rights>2018 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2018 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-48c29269d4adbef436f4af04b1905b85619188ec010804f22ca920b269fe4c683</citedby><cites>FETCH-LOGICAL-c4574-48c29269d4adbef436f4af04b1905b85619188ec010804f22ca920b269fe4c683</cites><orcidid>0000-0003-1041-0209 ; 0000-0001-5192-4682 ; 0000-0002-6249-6035 ; 0000-0001-7233-629X ; 0000-0002-7036-7305 ; 0000-0002-4959-2954 ; 0000-0002-1810-2203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.32704$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.32704$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30537354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tahira, Ana Carolina</creatorcontrib><creatorcontrib>Barbosa, André Rocha</creatorcontrib><creatorcontrib>Feltrin, Arthur Sant'Anna</creatorcontrib><creatorcontrib>Gastaldi, Vinicius Daguano</creatorcontrib><creatorcontrib>Toledo, Victor Hugo Calegari</creatorcontrib><creatorcontrib>Carvalho Pereira, José Geraldo</creatorcontrib><creatorcontrib>Lisboa, Bianca Cristina Garcia</creatorcontrib><creatorcontrib>Souza Reis, Viviane Neri</creatorcontrib><creatorcontrib>Santos, Ana Cecília Feio</creatorcontrib><creatorcontrib>Maschietto, Mariana</creatorcontrib><creatorcontrib>Brentani, Helena</creatorcontrib><title>Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am J Med Genet B Neuropsychiatr Genet</addtitle><description>The male‐biased prevalence of certain neurodevelopmental disorders and the sex‐biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP‐seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid‐gestation periods (FDR < 0.05), independent of sexual hormones. Genes with differential expression (24, p < 0.0001) and methylation (40, p < 0.047) between sexes were overrepresented in this set. Exclusive SOX3 or SRY target genes were more associated with the late gestational and postnatal periods. Using autism as a model sex‐biased disorder, the SOX3/SRY set was enriched in autism gene databases (FDR ≤ 0.05), and there were more de novo variations from the male autism spectrum disorder (ASD) samples under the SRY peaks compared to the random peaks (p < 0.024). The comparison of coexpressed networks of SOX3/SRY target genes between male autism and control samples revealed low preservation in gene modules related to stress response (99 genes) and neurogenesis (78 genes). This study provides evidence that while SOX3 is a regulatory mechanism for both sexes, the male‐exclusive SRY also plays a role in gene regulation, suggesting a potential mechanism for sex bias in ASD.</description><subject>Animals</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Databases, Genetic</subject><subject>DNA methylation</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation - genetics</subject><subject>Gene regulation</subject><subject>Gene Regulatory Networks</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genomes</subject><subject>Gestation</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>neurodevelopmental disorder</subject><subject>Neurodevelopmental disorders</subject><subject>Neurodevelopmental Disorders - genetics</subject><subject>Neurogenesis</subject><subject>Preservation</subject><subject>Risk Factors</subject><subject>sex</subject><subject>Sex Chromosomes - genetics</subject><subject>Sex Factors</subject><subject>Sex hormones</subject><subject>Sex-Determining Region Y Protein - genetics</subject><subject>Sex-Determining Region Y Protein - metabolism</subject><subject>Sexes</subject><subject>SOX3</subject><subject>SOXB1 Transcription Factors - genetics</subject><subject>SOXB1 Transcription Factors - metabolism</subject><subject>SRY</subject><subject>stress</subject><subject>Transcription Factors - genetics</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq2qFV_l1nNlqZce2MVfiZNLJYoKFIGoSivRk2U7E9arJN7azgL_Hi8Lq7aHnsbSPH40My9C7yiZUkLYoZ73t1Mz5UwS8Qrt0KJgE1EVN683b0G30W6Mc0I4KaTcQtu5cskLsYPMtzHp5JaArR9ScGZMzg8R-xanGeAI99jOgu999D3gRfAJXG5fX91wrIcGX3__hZPHA4zBN7CEzi96GJLucOOiDw2E-Ba9aXUXYf-57qGfJ19-HJ9NLq5Ovx4fXUysKKTIc1pWs7JuhG4MtIKXrdAtEYbWpDBVUdKaVhVYQklFRMuY1TUjJv9oQdiy4nvo09q7GE0Pjc1jBN2pRXC9Dg_Ka6f-7gxupm79UpWylILILPj4LAj-9wgxqd5FC12nB_BjVCzfk5YV4TyjH_5B534MQ15PMVZKLhmnK-HBmrLBxxig3QxDiVqFp1bhKaOewsv4-z8X2MAvaWVArIE718HDf2Xq6Pzy9PPa-wgnTKdf</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Tahira, Ana Carolina</creator><creator>Barbosa, André Rocha</creator><creator>Feltrin, Arthur Sant'Anna</creator><creator>Gastaldi, Vinicius Daguano</creator><creator>Toledo, Victor Hugo Calegari</creator><creator>Carvalho Pereira, José Geraldo</creator><creator>Lisboa, Bianca Cristina Garcia</creator><creator>Souza Reis, Viviane Neri</creator><creator>Santos, Ana Cecília Feio</creator><creator>Maschietto, Mariana</creator><creator>Brentani, Helena</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1041-0209</orcidid><orcidid>https://orcid.org/0000-0001-5192-4682</orcidid><orcidid>https://orcid.org/0000-0002-6249-6035</orcidid><orcidid>https://orcid.org/0000-0001-7233-629X</orcidid><orcidid>https://orcid.org/0000-0002-7036-7305</orcidid><orcidid>https://orcid.org/0000-0002-4959-2954</orcidid><orcidid>https://orcid.org/0000-0002-1810-2203</orcidid></search><sort><creationdate>201909</creationdate><title>Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders</title><author>Tahira, Ana Carolina ; Barbosa, André Rocha ; Feltrin, Arthur Sant'Anna ; Gastaldi, Vinicius Daguano ; Toledo, Victor Hugo Calegari ; Carvalho Pereira, José Geraldo ; Lisboa, Bianca Cristina Garcia ; Souza Reis, Viviane Neri ; Santos, Ana Cecília Feio ; Maschietto, Mariana ; Brentani, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-48c29269d4adbef436f4af04b1905b85619188ec010804f22ca920b269fe4c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Autism</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Databases, Genetic</topic><topic>DNA methylation</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation - genetics</topic><topic>Gene regulation</topic><topic>Gene Regulatory Networks</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genomes</topic><topic>Gestation</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>neurodevelopmental disorder</topic><topic>Neurodevelopmental disorders</topic><topic>Neurodevelopmental Disorders - genetics</topic><topic>Neurogenesis</topic><topic>Preservation</topic><topic>Risk Factors</topic><topic>sex</topic><topic>Sex Chromosomes - genetics</topic><topic>Sex Factors</topic><topic>Sex hormones</topic><topic>Sex-Determining Region Y Protein - genetics</topic><topic>Sex-Determining Region Y Protein - metabolism</topic><topic>Sexes</topic><topic>SOX3</topic><topic>SOXB1 Transcription Factors - genetics</topic><topic>SOXB1 Transcription Factors - metabolism</topic><topic>SRY</topic><topic>stress</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tahira, Ana Carolina</creatorcontrib><creatorcontrib>Barbosa, André Rocha</creatorcontrib><creatorcontrib>Feltrin, Arthur Sant'Anna</creatorcontrib><creatorcontrib>Gastaldi, Vinicius Daguano</creatorcontrib><creatorcontrib>Toledo, Victor Hugo Calegari</creatorcontrib><creatorcontrib>Carvalho Pereira, José Geraldo</creatorcontrib><creatorcontrib>Lisboa, Bianca Cristina Garcia</creatorcontrib><creatorcontrib>Souza Reis, Viviane Neri</creatorcontrib><creatorcontrib>Santos, Ana Cecília Feio</creatorcontrib><creatorcontrib>Maschietto, Mariana</creatorcontrib><creatorcontrib>Brentani, Helena</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tahira, Ana Carolina</au><au>Barbosa, André Rocha</au><au>Feltrin, Arthur Sant'Anna</au><au>Gastaldi, Vinicius Daguano</au><au>Toledo, Victor Hugo Calegari</au><au>Carvalho Pereira, José Geraldo</au><au>Lisboa, Bianca Cristina Garcia</au><au>Souza Reis, Viviane Neri</au><au>Santos, Ana Cecília Feio</au><au>Maschietto, Mariana</au><au>Brentani, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am J Med Genet B Neuropsychiatr Genet</addtitle><date>2019-09</date><risdate>2019</risdate><volume>180</volume><issue>6</issue><spage>390</spage><epage>414</epage><pages>390-414</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>The male‐biased prevalence of certain neurodevelopmental disorders and the sex‐biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP‐seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid‐gestation periods (FDR < 0.05), independent of sexual hormones. Genes with differential expression (24, p < 0.0001) and methylation (40, p < 0.047) between sexes were overrepresented in this set. Exclusive SOX3 or SRY target genes were more associated with the late gestational and postnatal periods. Using autism as a model sex‐biased disorder, the SOX3/SRY set was enriched in autism gene databases (FDR ≤ 0.05), and there were more de novo variations from the male autism spectrum disorder (ASD) samples under the SRY peaks compared to the random peaks (p < 0.024). The comparison of coexpressed networks of SOX3/SRY target genes between male autism and control samples revealed low preservation in gene modules related to stress response (99 genes) and neurogenesis (78 genes). 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| source | MEDLINE; Wiley Blackwell Single Titles |
| subjects | Animals Autism Autism Spectrum Disorder - genetics Databases, Genetic DNA methylation DNA-Binding Proteins - genetics Female Gene Expression Regulation - genetics Gene regulation Gene Regulatory Networks Genes Genetic Predisposition to Disease Genetics Genomes Gestation Humans Male Mice Mice, Inbred C57BL neurodevelopmental disorder Neurodevelopmental disorders Neurodevelopmental Disorders - genetics Neurogenesis Preservation Risk Factors sex Sex Chromosomes - genetics Sex Factors Sex hormones Sex-Determining Region Y Protein - genetics Sex-Determining Region Y Protein - metabolism Sexes SOX3 SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism SRY stress Transcription Factors - genetics |
| title | Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders |
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