Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model

Although midazolam is a frequently used sedative in neonatal intensive care units, its use in preterm neonates has been off‐label. Recently, a new dosing advice for midazolam for sedation on intensive care units has been included in the label (0.03 mg/[kg·h] for preterm neonates 32 weeks). Concentra...

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Veröffentlicht in:	Journal of clinical pharmacology 2019-10, Vol.59 (10), p.1300-1308
Hauptverfasser:	Völler, Swantje, Flint, Robert B., Beggah, Fouzi, Reiss, Irwin, Andriessen, Peter, Zimmermann, Luc J.I., den Anker, John N., Liem, Kian D., Koch, Birgit C.P., Wildt, Saskia, Knibbe, Catherijne A.J., Simons, Sinno H.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Body weight Computer simulation Dosage drug metabolism Exposure fetal medicine Gestational age Intensive care Intensive care units Midazolam Neonates neonatology Newborn babies Pediatric Pharmacology Pharmacokinetics pharmacometrics population pharmacokinetics Weighing
Online-Zugang:	Volltext
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