Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study
The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue‐reactivity paradigms in substance using populat...
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| Veröffentlicht in: | The European journal of neuroscience 2019-08, Vol.50 (3), p.2357-2369 |
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| container_title | The European journal of neuroscience |
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| creator | Prashad, Shikha Dedrick, Elizabeth S. To, Wing Ting Vanneste, Sven Filbey, Francesca M. |
| description | The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue‐reactivity paradigms in substance using populations. These studies suggest that the PCC and precuneus may underlie deficits in processing salient stimuli that contribute toward the development of substance use disorders. The goal of this study was to directly test this hypothesis using repetitive transcranial magnetic stimulation (rTMS). Using a double‐blind, placebo‐controlled design, we used rTMS to target the PCC and precuneus with a double‐cone coil at 10 Hz (high frequency) and 1 Hz (low frequency) in 10 adult cannabis users and 10 age‐ and sex‐matched non‐using controls. Electroencephalography data were collected before and after rTMS during a modified oddball paradigm with neutral, oddball, self‐relevant, and cannabis‐related stimuli. Cannabis users exhibited increased amplitude in P3 and faster latencies in the P3, N2, and P2 components in response to self‐relevant stimuli compared to controls during baseline that normalized after rTMS. These results suggest that cannabis users exhibited heightened salience to external self‐relevant stimuli that were modulated after rTMS. PCC dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.
Cannabis users’ enhanced event‐related potential response to salient stimuli decreased after repetitive transcranial magnetic stimulation targeting the posterior cingulate cortex. This result suggests that dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention. |
| doi_str_mv | 10.1111/ejn.14194 |
| format | Article |
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Cannabis users’ enhanced event‐related potential response to salient stimuli decreased after repetitive transcranial magnetic stimulation targeting the posterior cingulate cortex. This result suggests that dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.14194</identifier><identifier>PMID: 30290037</identifier><language>eng</language><publisher>France: Wiley Subscription Services, Inc</publisher><subject>Addiction Special Issue ; Cannabis ; Cortex (cingulate) ; Cortex (parietal) ; Drug abuse ; EEG ; EEG ERP ; Event-related potentials ; exteroceptive processes ; Magnetic fields ; Marijuana ; neuromodulation ; Population studies ; posterior cingulate cortex ; precuneus ; Special Issue ; Transcranial magnetic stimulation</subject><ispartof>The European journal of neuroscience, 2019-08, Vol.50 (3), p.2357-2369</ispartof><rights>2018 The Authors. published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4434-576b7e43ce5400fe75afdd3119cfe10272acb811829b8cbfa0d90ee02d8e994e3</citedby><cites>FETCH-LOGICAL-c4434-576b7e43ce5400fe75afdd3119cfe10272acb811829b8cbfa0d90ee02d8e994e3</cites><orcidid>0000-0002-7466-4796</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.14194$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.14194$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30290037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prashad, Shikha</creatorcontrib><creatorcontrib>Dedrick, Elizabeth S.</creatorcontrib><creatorcontrib>To, Wing Ting</creatorcontrib><creatorcontrib>Vanneste, Sven</creatorcontrib><creatorcontrib>Filbey, Francesca M.</creatorcontrib><title>Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue‐reactivity paradigms in substance using populations. These studies suggest that the PCC and precuneus may underlie deficits in processing salient stimuli that contribute toward the development of substance use disorders. The goal of this study was to directly test this hypothesis using repetitive transcranial magnetic stimulation (rTMS). Using a double‐blind, placebo‐controlled design, we used rTMS to target the PCC and precuneus with a double‐cone coil at 10 Hz (high frequency) and 1 Hz (low frequency) in 10 adult cannabis users and 10 age‐ and sex‐matched non‐using controls. Electroencephalography data were collected before and after rTMS during a modified oddball paradigm with neutral, oddball, self‐relevant, and cannabis‐related stimuli. Cannabis users exhibited increased amplitude in P3 and faster latencies in the P3, N2, and P2 components in response to self‐relevant stimuli compared to controls during baseline that normalized after rTMS. These results suggest that cannabis users exhibited heightened salience to external self‐relevant stimuli that were modulated after rTMS. PCC dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.
Cannabis users’ enhanced event‐related potential response to salient stimuli decreased after repetitive transcranial magnetic stimulation targeting the posterior cingulate cortex. This result suggests that dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.</description><subject>Addiction Special Issue</subject><subject>Cannabis</subject><subject>Cortex (cingulate)</subject><subject>Cortex (parietal)</subject><subject>Drug abuse</subject><subject>EEG</subject><subject>EEG ERP</subject><subject>Event-related potentials</subject><subject>exteroceptive processes</subject><subject>Magnetic fields</subject><subject>Marijuana</subject><subject>neuromodulation</subject><subject>Population studies</subject><subject>posterior cingulate cortex</subject><subject>precuneus</subject><subject>Special Issue</subject><subject>Transcranial magnetic stimulation</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kU9vFCEYh4nR2LV68AsYEi96mJZ_w4CHJqapVVP14Jp4IwzzTsuGhS3MqPvty3ZroyZygeT38OSFH0LPKTmidR3DKh5RQbV4gBZUSNLoVqqHaEF0yxtF5fcD9KSUFSFESdE-RgecME0I7xboegll8vEST1eAcwqA03h73qQyQfYpY1fjOdgJsEt5gl_YR7zJyUEpu4vFBg9xwlWznoPfpc7GaHtf8FwglzfYRpyXn75WZB62T9Gj0YYCz-72Q_Tt3dny9H1z8eX8w-nbi8YJwUXTdrLvQHAHrSBkhK614zBwSrUbgRLWMet6RaliuleuHy0ZNAEgbFCgtQB-iE723s3cr2FwdcZsg9lkv7Z5a5L15u8k-itzmX4Y2cmOtLIKXt0Jcrqe6zeZtS8OQrAR0lwMo1SqlnJJK_ryH3SV5hzr8wxjquOMCCoq9XpPuZxKyTDeD0OJ2RVpapHmtsjKvvhz-nvyd3MVON4DP32A7f9N5uzj573yBrwZqds</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Prashad, Shikha</creator><creator>Dedrick, Elizabeth S.</creator><creator>To, Wing Ting</creator><creator>Vanneste, Sven</creator><creator>Filbey, Francesca M.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7466-4796</orcidid></search><sort><creationdate>201908</creationdate><title>Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study</title><author>Prashad, Shikha ; Dedrick, Elizabeth S. ; To, Wing Ting ; Vanneste, Sven ; Filbey, Francesca M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4434-576b7e43ce5400fe75afdd3119cfe10272acb811829b8cbfa0d90ee02d8e994e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Addiction Special Issue</topic><topic>Cannabis</topic><topic>Cortex (cingulate)</topic><topic>Cortex (parietal)</topic><topic>Drug abuse</topic><topic>EEG</topic><topic>EEG ERP</topic><topic>Event-related potentials</topic><topic>exteroceptive processes</topic><topic>Magnetic fields</topic><topic>Marijuana</topic><topic>neuromodulation</topic><topic>Population studies</topic><topic>posterior cingulate cortex</topic><topic>precuneus</topic><topic>Special Issue</topic><topic>Transcranial magnetic stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prashad, Shikha</creatorcontrib><creatorcontrib>Dedrick, Elizabeth S.</creatorcontrib><creatorcontrib>To, Wing Ting</creatorcontrib><creatorcontrib>Vanneste, Sven</creatorcontrib><creatorcontrib>Filbey, Francesca M.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prashad, Shikha</au><au>Dedrick, Elizabeth S.</au><au>To, Wing Ting</au><au>Vanneste, Sven</au><au>Filbey, Francesca M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2019-08</date><risdate>2019</risdate><volume>50</volume><issue>3</issue><spage>2357</spage><epage>2369</epage><pages>2357-2369</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue‐reactivity paradigms in substance using populations. These studies suggest that the PCC and precuneus may underlie deficits in processing salient stimuli that contribute toward the development of substance use disorders. The goal of this study was to directly test this hypothesis using repetitive transcranial magnetic stimulation (rTMS). Using a double‐blind, placebo‐controlled design, we used rTMS to target the PCC and precuneus with a double‐cone coil at 10 Hz (high frequency) and 1 Hz (low frequency) in 10 adult cannabis users and 10 age‐ and sex‐matched non‐using controls. Electroencephalography data were collected before and after rTMS during a modified oddball paradigm with neutral, oddball, self‐relevant, and cannabis‐related stimuli. Cannabis users exhibited increased amplitude in P3 and faster latencies in the P3, N2, and P2 components in response to self‐relevant stimuli compared to controls during baseline that normalized after rTMS. These results suggest that cannabis users exhibited heightened salience to external self‐relevant stimuli that were modulated after rTMS. PCC dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.
Cannabis users’ enhanced event‐related potential response to salient stimuli decreased after repetitive transcranial magnetic stimulation targeting the posterior cingulate cortex. This result suggests that dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.</abstract><cop>France</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30290037</pmid><doi>10.1111/ejn.14194</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7466-4796</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Addiction Special Issue Cannabis Cortex (cingulate) Cortex (parietal) Drug abuse EEG EEG ERP Event-related potentials exteroceptive processes Magnetic fields Marijuana neuromodulation Population studies posterior cingulate cortex precuneus Special Issue Transcranial magnetic stimulation |
| title | Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study |
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