CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease

Background Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. Results The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. Conclusion In this review, we focus on the role of CXCR4/CXCL...

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Veröffentlicht in:	European journal of clinical investigation 2018-11, Vol.48 (S2), p.e12949-n/a
Hauptverfasser:	De Filippo, Katia, Rankin, Sara M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzylamines - pharmacology Bone marrow Bone Marrow - physiology Cell Survival - physiology Chemokine CXCL12 - genetics Chemokine CXCL12 - physiology Chemokines clearance CXCL12 protein CXCR4 CXCR4 protein Hematologic Agents - pharmacology Heterocyclic Compounds - pharmacology HMGB1 Protein - physiology Homeostasis Homeostasis - physiology Humans Imidazoles - pharmacology Immunologic Deficiency Syndromes - genetics Inflammation - physiopathology Leukocytes (neutrophilic) Mice mobilization Mutation - physiology Neutrophils Neutrophils - drug effects Neutrophils - physiology Neutrophils. Guest Editor: Dirk Roos Peptide Fragments - pharmacology Primary Immunodeficiency Diseases Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - physiology retention Review Serum Albumin - pharmacology Spleen - physiology Warts - genetics
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