Doxorubicin‐induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

ABSTRACT Doxorubicin (Dox) is a widely used antineoplastic agent that can cause heart failure. Dox cardiotoxicity is closely associated with mitochondrial damage. Mitochondrial fission and mitophagy are quality control mechanisms that normally help maintain a pool of healthy mitochondria. However, u...

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Veröffentlicht in:	The FASEB journal 2019-10, Vol.33 (10), p.11096-11108
Hauptverfasser:	Catanzaro, Michael P., Weiner, Ashley, Kaminaris, Amanda, Li, Cairong, Cai, Fei, Zhao, Fengyi, Kobayashi, Satoru, Kobayashi, Tamayo, Huang, Yuan, Sesaki, Hiromi, Liang, Qiangrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-tumor agents cardiotoxicity Cardiotoxicity - etiology Cardiotoxicity - metabolism Caspase 3 - metabolism Cell Death - drug effects Cell Line Doxorubicin - pharmacology Dynamins - metabolism Female heart failure Humans Male Mice Mice, Knockout Mitochondria - drug effects Mitochondrial Dynamics - drug effects mitochondrial quality control Mitophagy - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Rats RNA, Small Interfering - metabolism Ubiquitin-Protein Ligases - metabolism
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