Sphingosine-1-phosphate signaling in blood pressure regulation
Sphingolipids were originally believed to play a role only as a backbone of mammalian cell membranes. However, sphingolipid metabolites, especially sphingosine-1-phosphate (S1P), are now recognized as new bioactive signaling molecules that are critically involved in numerous cellular functions of mu...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 2019-09, Vol.317 (3), p.F638-F640 |
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| container_title | American journal of physiology. Renal physiology |
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| creator | Intapad, Suttira |
| description | Sphingolipids were originally believed to play a role only as a backbone of mammalian cell membranes. However, sphingolipid metabolites, especially sphingosine-1-phosphate (S1P), are now recognized as new bioactive signaling molecules that are critically involved in numerous cellular functions of multiple systems including the immune system, central nervous system, and cardiovascular system. S1P research has accelerated in the last decade as new therapeutic drugs have emerged that target the S1P signaling axis to treat diseases of the immune and central nervous systems. There is limited knowledge of the specific effects on cardiovascular disease. This review discusses the current state of knowledge regarding the role of S1P on the regulation of blood pressure, vascular tone, and renal functions. |
| doi_str_mv | 10.1152/ajprenal.00572.2018 |
| format | Article |
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This review discusses the current state of knowledge regarding the role of S1P on the regulation of blood pressure, vascular tone, and renal functions.</description><subject>Animals</subject><subject>Arteries - metabolism</subject><subject>Blood Pressure</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Lysophospholipids - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - metabolism</subject><subject>Sphingosine-1-Phosphate Receptors - metabolism</subject><subject>Vasoconstriction</subject><subject>Vasodilation</subject><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN1LwzAUxYMobk7_AkH66EtnbtIm7ctAxC8Y-KCCbyFNsy6jS2rSCv73Zu4DfboXzrnnHn4IXQKeAuTkRq46r61spxjnnEwJhuIIjaNCUsgYO457SSEtcv4xQmchrDDGAARO0YgCLTFhbIxmr93S2MYFY3UKabd0oVvKXifBNDE7SomxSdU6VyfxXQiD14nXzdDK3jh7jk4Wsg36Yjcn6P3h_u3uKZ2_PD7f3c5TlXHoU15ITHCpYFHLogZeljnXRFJGFGaVUrKsY9WcqgozrnNexIIkg6LGoIBXjE7QbJvbDdVa10rb3stWdN6spf8WThrxX7FmKRr3JRhnjNE8BlzvArz7HHToxdoEpdtWWu2GIAjheMORZtFKt1blXQheLw5vAIsNebEnL37Jiw35eHX1t-HhZo-a_gDCioIX</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Intapad, Suttira</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Sphingosine-1-phosphate signaling in blood pressure regulation</title><author>Intapad, Suttira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-78a0209c1fda8d179957e2a362c06bcca9d93153cb067e5783132418d01c17b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Arteries - metabolism</topic><topic>Blood Pressure</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Lysophospholipids - metabolism</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - metabolism</topic><topic>Sphingosine-1-Phosphate Receptors - metabolism</topic><topic>Vasoconstriction</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Intapad, Suttira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. 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| identifier | ISSN: 1931-857X |
| ispartof | American journal of physiology. Renal physiology, 2019-09, Vol.317 (3), p.F638-F640 |
| issn | 1931-857X 1522-1466 |
| language | eng |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Arteries - metabolism Blood Pressure Homeostasis Humans Kidney - metabolism Lysophospholipids - metabolism Review Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine-1-Phosphate Receptors - metabolism Vasoconstriction Vasodilation |
| title | Sphingosine-1-phosphate signaling in blood pressure regulation |
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