Enhancing the Efficacy of Melanocortin 1 Receptor-Targeted Radiotherapy by Pharmacologically Upregulating the Receptor in Metastatic Melanoma

Melanocortin 1 receptor (MC1R) is under investigation as a target for drug delivery for metastatic melanoma therapy and imaging. The purpose of this study was to determine the potential of using BRAF inhibitors (BRAFi) and histone deacetylase inhibitors (HDACi) to enhance the delivery of MC1R-target...

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Veröffentlicht in:	Molecular pharmaceutics 2019-09, Vol.16 (9), p.3904-3915
Hauptverfasser:	Li, Mengshi, Liu, Dijie, Lee, Dongyoul, Kapoor, Somya, Gibson-Corley, Katherine N, Quinn, Thomas P, Sagastume, Edwin A, Mott, Sarah L, Walsh, Susan A, Acevedo, Michael R, Johnson, Frances L, Schultz, Michael K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha Particles - therapeutic use Animals Cell Line, Tumor Combined Modality Therapy Drug Delivery Systems - methods Female Histone Deacetylase Inhibitors - pharmacology Humans Imidazoles - pharmacology Lead Radioisotopes - chemistry Melanoma - drug therapy Melanoma - pathology Melanoma - radiotherapy Mice, Nude Microphthalmia-Associated Transcription Factor Oximes - pharmacology Phenylbutyrates - pharmacology Pilot Projects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Real-Time Polymerase Chain Reaction Receptor, Melanocortin, Type 1 - genetics Receptor, Melanocortin, Type 1 - metabolism Single Photon Emission Computed Tomography Computed Tomography Skin Neoplasms - drug therapy Skin Neoplasms - pathology Skin Neoplasms - radiotherapy Tumor Burden - drug effects Up-Regulation - drug effects Xenograft Model Antitumor Assays
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