DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

Abstract The DNA damage response (DDR) encompasses the cellular response to DNA double-stranded breaks (DSBs), and includes recognition of the DSB, recruitment of numerous factors to the DNA damage site, initiation of signaling cascades, chromatin remodeling, cell-cycle checkpoint activation, and re...

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Veröffentlicht in:	Nucleic acids research 2019-10, Vol.47 (18), p.9467-9479
Hauptverfasser:	Lu, Huiming, Saha, Janapriya, Beckmann, Pauline J, Hendrickson, Eric A, Davis, Anthony J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - genetics Cell Cycle Checkpoints - genetics Chromatin - genetics DNA - genetics DNA Breaks, Double-Stranded - radiation effects DNA Damage - genetics DNA Damage - radiation effects DNA Repair - genetics DNA-Activated Protein Kinase - genetics Humans NAR Breakthrough Nuclear Proteins - genetics Phosphorylation - radiation effects Radiation, Ionizing Signal Transduction - genetics Signal Transduction - radiation effects
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