Insights into the base-pairing preferences of 8-oxoguanosine on the ribosome

Abstract Of the four bases, guanine is the most susceptible to oxidation, which results in the formation of 8-oxoguanine (8-oxoG). In protein-free DNA, 8-oxodG adopts the syn conformation more frequently than the anti one. In the syn conformation, 8-oxodG base pairs with dA. The equilibrium between...

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Veröffentlicht in:	Nucleic acids research 2019-10, Vol.47 (18), p.9857-9870
Hauptverfasser:	Thomas, Erica N, Simms, Carrie L, Keedy, Hannah E, Zaher, Hani S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anticodon - chemistry Anticodon - genetics Base Pairing - genetics DNA Damage - genetics Escherichia coli - genetics Guanine - chemistry Guanosine - analogs & derivatives Guanosine - chemistry Guanosine - genetics Mutation - drug effects Nucleic Acid Conformation Oxidation-Reduction Ribosomes - chemistry Ribosomes - genetics RNA and RNA-protein complexes RNA, Messenger - genetics RNA, Transfer RNA, Transfer, Amino Acyl - drug effects
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