NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma

Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated uterine sarcoma. NTRK rearrangements were detected b...

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Veröffentlicht in:	The American journal of surgical pathology 2018-06, Vol.42 (6), p.791-798
Hauptverfasser:	Chiang, Sarah, Cotzia, Paolo, Hyman, David M, Drilon, Alexander, Tap, William D, Zhang, Lei, Hechtman, Jaclyn F, Frosina, Denise, Jungbluth, Achim A, Murali, Rajmohan, Park, Kay J, Soslow, Robert A, Oliva, Esther, Iafrate, A John, Benayed, Ryma, Ladanyi, Marc, Antonescu, Cristina R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Diagnosis, Differential Female Fibrosarcoma - chemistry Fibrosarcoma - genetics Fibrosarcoma - pathology Gene Fusion Gene Rearrangement Genetic Predisposition to Disease Humans Immunohistochemistry In Situ Hybridization, Fluorescence Leiomyosarcoma - chemistry Leiomyosarcoma - genetics Leiomyosarcoma - pathology Middle Aged Mitotic Index Phenotype Predictive Value of Tests Prospective Studies Receptor, trkA - analysis Receptor, trkA - genetics Receptor, trkC - analysis Receptor, trkC - genetics Sarcoma - chemistry Sarcoma - genetics Sarcoma - pathology Uterine Neoplasms - chemistry Uterine Neoplasms - genetics Uterine Neoplasms - pathology Whole Exome Sequencing
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