Effects of locally applied Insulin-like Growth Factor-I on osseointegration

The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce exper...

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Veröffentlicht in:	Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2019-09, Vol.24 (5), p.e652-e658
Hauptverfasser:	López-Quiles, J, Forteza-López, A, Montiel, M, Clemente, C, Fernández-Tresguerres, J-A, Fernández-Tresguerres, I
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Sprache:	eng
Schlagworte:	Animals Bone Density Dental Implants Female Humans Insulin-Like Growth Factor I Osseointegration Osteoporosis Rabbits Titanium
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creator	López-Quiles, J Forteza-López, A Montiel, M Clemente, C Fernández-Tresguerres, J-A Fernández-Tresguerres, I
description	The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P
doi_str_mv	10.4317/medoral.22973
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A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.22973</identifier><identifier>PMID: 31433388</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Animals ; Bone Density ; Dental Implants ; Female ; Humans ; Insulin-Like Growth Factor I ; Osseointegration ; Osteoporosis ; Rabbits ; Titanium</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2019-09, Vol.24 (5), p.e652-e658</ispartof><rights>Copyright: © 2019 Medicina Oral S.L. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764712/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764712/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31433388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>López-Quiles, J</creatorcontrib><creatorcontrib>Forteza-López, A</creatorcontrib><creatorcontrib>Montiel, M</creatorcontrib><creatorcontrib>Clemente, C</creatorcontrib><creatorcontrib>Fernández-Tresguerres, J-A</creatorcontrib><creatorcontrib>Fernández-Tresguerres, I</creatorcontrib><title>Effects of locally applied Insulin-like Growth Factor-I on osseointegration</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.</description><subject>Animals</subject><subject>Bone Density</subject><subject>Dental Implants</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I</subject><subject>Osseointegration</subject><subject>Osteoporosis</subject><subject>Rabbits</subject><subject>Titanium</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkb1PwzAQxS0EoqUwsqKMLCn-iJ14QUJVWyoqscBsOY7dGtw42Amo_z2BlqpMd9L99O7ePQCuERxnBOV3G135IN0YY56TEzBEjBcp4xk7PeoH4CLGNwhJjnJ2DgYEZYSQohiCp6kxWrUx8SZxXknntolsGmd1lSzq2Dlbp86-62Qe_Fe7TmZStT6ki8TXiY9Re1u3ehVka319Cc6MdFFf7esIvM6mL5PHdPk8X0welqkiGWlTpBlkvGIMcUw0pRxDrGlmEJRlZTCjBZZUlpyoglEjK1WV1HCa5TkuDcaQjMD9Trfpyt6-0nXbf0A0wW5k2Aovrfg_qe1arPynYDnLcoR7gdu9QPAfnY6t2NiotHOy1r6LAuOCIARpxns03aEq9HaDNoc1CIqfAMQ-APEbQM_fHN92oP8-Tr4Bq7GD_Q</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>López-Quiles, J</creator><creator>Forteza-López, A</creator><creator>Montiel, M</creator><creator>Clemente, C</creator><creator>Fernández-Tresguerres, J-A</creator><creator>Fernández-Tresguerres, I</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190901</creationdate><title>Effects of locally applied Insulin-like Growth Factor-I on osseointegration</title><author>López-Quiles, J ; Forteza-López, A ; Montiel, M ; Clemente, C ; Fernández-Tresguerres, J-A ; Fernández-Tresguerres, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-1e6069d661923e559202e54f10abdf26582a5ab93c865fadcdb5f954772bf2203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Bone Density</topic><topic>Dental Implants</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I</topic><topic>Osseointegration</topic><topic>Osteoporosis</topic><topic>Rabbits</topic><topic>Titanium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Quiles, J</creatorcontrib><creatorcontrib>Forteza-López, A</creatorcontrib><creatorcontrib>Montiel, M</creatorcontrib><creatorcontrib>Clemente, C</creatorcontrib><creatorcontrib>Fernández-Tresguerres, J-A</creatorcontrib><creatorcontrib>Fernández-Tresguerres, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>López-Quiles, J</au><au>Forteza-López, A</au><au>Montiel, M</au><au>Clemente, C</au><au>Fernández-Tresguerres, J-A</au><au>Fernández-Tresguerres, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of locally applied Insulin-like Growth Factor-I on osseointegration</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>24</volume><issue>5</issue><spage>e652</spage><epage>e658</epage><pages>e652-e658</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>31433388</pmid><doi>10.4317/medoral.22973</doi><oa>free_for_read</oa></addata></record>
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subjects	Animals Bone Density Dental Implants Female Humans Insulin-Like Growth Factor I Osseointegration Osteoporosis Rabbits Titanium
title	Effects of locally applied Insulin-like Growth Factor-I on osseointegration
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