Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases

Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enhances the activity of phosphoglycerate kina...

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Veröffentlicht in:	The Journal of clinical investigation 2019-10, Vol.129 (10), p.4539-4549
Hauptverfasser:	Cai, Rong, Zhang, Yu, Simmering, Jacob E, Schultz, Jordan L, Li, Yuhong, Fernandez-Carasa, Irene, Consiglio, Antonella, Raya, Angel, Polgreen, Philip M, Narayanan, Nandakumar S, Yuan, Yanpeng, Chen, Zhiguo, Su, Wenting, Han, Yanping, Zhao, Chunyue, Gao, Lifang, Ji, Xunming, Welsh, Michael J, Liu, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aged Aged, 80 and over Alzheimer's disease Animal models Animals Binding sites Biomedical research Biosynthesis Brain - drug effects Brain - metabolism Brain stem Dementia Disease Progression Dopamine Dopamine - metabolism Drosophila melanogaster - drug effects Drosophila melanogaster - metabolism Energy metabolism Female Glucose metabolism Glycolysis Glycolysis - drug effects Humans Hypertension Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Insulin Kinases Male Metabolism Mice Mice, Inbred C57BL Mitochondrial DNA Movement disorders Mutation Nerve Degeneration - drug therapy Neurodegeneration Neurodegenerative diseases Neurons Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Parkinsonian Disorders - drug therapy Parkinsonian Disorders - metabolism Phenols (Class of compounds) Phosphoglycerate kinase Phosphoglycerate Kinase - metabolism Phosphoglycerate kinase 1 Phosphorylation Physiological aspects Pluripotency Prazosin - analogs & derivatives Prazosin - pharmacology Rats Stem cell transplantation Stem cells
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