Modeling Circadian Oscillations with Interlocking Positive and Negative Feedback Loops

Both positive and negative feedback loops of transcriptional regulation have been proposed to be important for the generation of circadian rhythms. To test the sufficiency of the proposed mechanisms, two differential equation-based models were constructed to describe the Neurospora crassa and Drosop...

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Veröffentlicht in:	The Journal of neuroscience 2001-09, Vol.21 (17), p.6644-6656
Hauptverfasser:	Smolen, Paul, Baxter, Douglas A, Byrne, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Clocks - physiology Biological Clocks - radiation effects Circadian Rhythm - physiology Circadian Rhythm - radiation effects CLOCK Proteins Computer Simulation DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster Drosophila Proteins Feedback - physiology Feedback - radiation effects Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation - physiology Insect Proteins - metabolism Light Macromolecular Substances Models, Biological Neurospora Neurospora crassa Nuclear Proteins - metabolism Period Circadian Proteins Phosphorylation Predictive Value of Tests Protein Binding - physiology Reproducibility of Results Transcription Factors - metabolism
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