Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

It is common clinical experience that anxiety about pain can exacerbate the pain sensation. Using event-related functional magnetic resonance imaging (FMRI), we compared activation responses to noxious thermal stimulation while perceived pain intensity was manipulated by changes in either physical i...

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Veröffentlicht in:	The Journal of neuroscience 2001-12, Vol.21 (24), p.9896-9903
Hauptverfasser:	Ploghaus, Alexander, Narain, Charvy, Beckmann, Christian F, Clare, Stuart, Bantick, Susanna, Wise, Richard, Matthews, Paul M, Rawlins, J. Nicholas P, Tracey, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety - complications Anxiety - physiopathology Behavior Brain Mapping Conditioning, Classical Entorhinal Cortex - anatomy & histology Entorhinal Cortex - physiopathology Heart Rate Hippocampus - anatomy & histology Hippocampus - physiopathology Hot Temperature Humans Hyperalgesia - complications Hyperalgesia - physiopathology Magnetic Resonance Imaging Male Nerve Net - physiopathology Pain - complications Pain - physiopathology Parahippocampal Gyrus - anatomy & histology Parahippocampal Gyrus - physiopathology Physical Stimulation
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