Neuronal P2X7 Receptors Are Targeted to Presynaptic Terminals in the Central and Peripheral Nervous Systems

The ionotropic ATP receptor subunits P2X(1-6) receptors play important roles in synaptic transmission, yet the P2X(7) receptor has been reported as absent from neurons in the normal adult brain. Here we use RT-PCR to demonstrate that transcripts for the P2X(7) receptor are present in extracts from t...

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Veröffentlicht in:	The Journal of neuroscience 2001-09, Vol.21 (18), p.7143-7152
Hauptverfasser:	Deuchars, Susan A, Atkinson, Lucy, Brooke, Ruth E, Musa, Hanny, Milligan, Carol J, Batten, Trevor F. C, Buckley, Noel J, Parson, Simon H, Deuchars, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System - chemistry Central Nervous System - cytology Central Nervous System - metabolism Glutamic Acid - metabolism Immunohistochemistry In Situ Hybridization Male Medulla Oblongata - chemistry Medulla Oblongata - cytology Medulla Oblongata - metabolism Mice Mice, Inbred C57BL Muscle, Skeletal - innervation Neuromuscular Junction - metabolism Neurons - cytology Neurons - metabolism Neurotransmitter Agents - metabolism Nodose Ganglion - chemistry Nodose Ganglion - cytology Nodose Ganglion - metabolism Patch-Clamp Techniques Peripheral Nervous System - chemistry Peripheral Nervous System - cytology Peripheral Nervous System - metabolism Presynaptic Terminals - metabolism Rats Rats, Wistar Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X7 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - biosynthesis Spinal Cord - chemistry Spinal Cord - cytology Spinal Cord - metabolism Synaptic Transmission - physiology
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