Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis

Superior cervical ganglion (SCG) sympathetic neurons die by apoptosis when deprived of nerve growth factor (NGF). It has been shown previously that the induction of apoptosis in these neurons at NGF withdrawal requires both the activity of the small GTP-binding protein Cdc42 and the activation of th...

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Veröffentlicht in:	The Journal of neuroscience 2001-07, Vol.21 (14), p.4949-4957
Hauptverfasser:	Mota, Monica, Reeder, Melissa, Chernoff, Jonathan, Bazenet, Chantal E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - physiology Animals Apoptosis - drug effects Apoptosis - physiology c-Jun amino-terminal kinase cdc42 GTP-Binding Protein - metabolism cdc42 GTP-Binding Protein - pharmacology Cell Line Cell Survival - drug effects Cells, Cultured Enzyme Activation - drug effects Enzyme Activation - genetics Gene Expression Genes, Dominant Humans JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Kinase Kinases - pharmacology Microinjections Mitogen-Activated Protein Kinase Kinase Kinase 11 Mitogen-Activated Protein Kinases - metabolism mixed lineage kinase 3 Mutagenesis, Site-Directed Nerve Growth Factor - pharmacology Neurons - cytology Neurons - drug effects Neurons - enzymology Phosphorylation - drug effects Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - pharmacology Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology Superior Cervical Ganglion
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