Parabrachial Internal Lateral Neurons Convey Nociceptive Messages from the Deep Laminas of the Dorsal Horn to the Intralaminar Thalamus
This study investigates the physiological properties of parabrachial internal lateral (PBil) neurons that project to the paracentral thalamic (PC) nucleus using antidromic activation and single-unit recording techniques in anesthetized rat. We reported here that most of these neurons responded exclu...
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| Veröffentlicht in: | The Journal of neuroscience 2001-03, Vol.21 (6), p.2159-2165 |
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| creator | Bourgeais, Laurence Monconduit, Lenaic Villanueva, Luis Bernard, Jean-Francois |
| description | This study investigates the physiological properties of parabrachial internal lateral (PBil) neurons that project to the paracentral thalamic (PC) nucleus using antidromic activation and single-unit recording techniques in anesthetized rat. We reported here that most of these neurons responded exclusively to the nociceptive stimulation of large receptive fields with a sustained firing that often outlasted the stimulus up to several minutes. These responses were depressed by intravenous morphine. Our results demonstrated a novel spino-PBil-PC pathway, which transmits nociceptive messages to the PC nucleus, which in turn projects to the prefrontal cortex. Recent clinical imaging studies showed the important participation of prefrontal cortex in emotional response to pain. This spino-PBil-PC pathway may explain how nociceptive messages reach the prefrontal cortex and thus trigger unbearable aversive aspects of pain. |
| doi_str_mv | 10.1523/jneurosci.21-06-02159.2001 |
| format | Article |
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We reported here that most of these neurons responded exclusively to the nociceptive stimulation of large receptive fields with a sustained firing that often outlasted the stimulus up to several minutes. These responses were depressed by intravenous morphine. Our results demonstrated a novel spino-PBil-PC pathway, which transmits nociceptive messages to the PC nucleus, which in turn projects to the prefrontal cortex. Recent clinical imaging studies showed the important participation of prefrontal cortex in emotional response to pain. This spino-PBil-PC pathway may explain how nociceptive messages reach the prefrontal cortex and thus trigger unbearable aversive aspects of pain.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/jneurosci.21-06-02159.2001</identifier><identifier>PMID: 11245700</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Afferent Pathways - cytology ; Afferent Pathways - drug effects ; Afferent Pathways - physiology ; Animals ; Electric Stimulation ; Evoked Potentials - physiology ; Intralaminar Thalamic Nuclei - cytology ; Intralaminar Thalamic Nuclei - physiology ; Male ; Morphine - pharmacology ; Narcotic Antagonists - pharmacology ; Narcotics - pharmacology ; Pain ; Pain Measurement ; Physical Stimulation ; Posterior Horn Cells - cytology ; Posterior Horn Cells - drug effects ; Posterior Horn Cells - physiology ; Prefrontal Cortex - physiology ; Rats ; Rats, Sprague-Dawley ; Reaction Time - physiology ; Touch - physiology</subject><ispartof>The Journal of neuroscience, 2001-03, Vol.21 (6), p.2159-2165</ispartof><rights>Copyright © 2001 Society for Neuroscience 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-c383c531118db3328b7c7bd923deac3e84bfbef737bf51bbe9ef39d801ee4c173</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762611/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762611/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11245700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bourgeais, Laurence</creatorcontrib><creatorcontrib>Monconduit, Lenaic</creatorcontrib><creatorcontrib>Villanueva, Luis</creatorcontrib><creatorcontrib>Bernard, Jean-Francois</creatorcontrib><title>Parabrachial Internal Lateral Neurons Convey Nociceptive Messages from the Deep Laminas of the Dorsal Horn to the Intralaminar Thalamus</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>This study investigates the physiological properties of parabrachial internal lateral (PBil) neurons that project to the paracentral thalamic (PC) nucleus using antidromic activation and single-unit recording techniques in anesthetized rat. We reported here that most of these neurons responded exclusively to the nociceptive stimulation of large receptive fields with a sustained firing that often outlasted the stimulus up to several minutes. These responses were depressed by intravenous morphine. Our results demonstrated a novel spino-PBil-PC pathway, which transmits nociceptive messages to the PC nucleus, which in turn projects to the prefrontal cortex. Recent clinical imaging studies showed the important participation of prefrontal cortex in emotional response to pain. This spino-PBil-PC pathway may explain how nociceptive messages reach the prefrontal cortex and thus trigger unbearable aversive aspects of pain.</description><subject>Afferent Pathways - cytology</subject><subject>Afferent Pathways - drug effects</subject><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Electric Stimulation</subject><subject>Evoked Potentials - physiology</subject><subject>Intralaminar Thalamic Nuclei - cytology</subject><subject>Intralaminar Thalamic Nuclei - physiology</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - pharmacology</subject><subject>Pain</subject><subject>Pain Measurement</subject><subject>Physical Stimulation</subject><subject>Posterior Horn Cells - cytology</subject><subject>Posterior Horn Cells - drug effects</subject><subject>Posterior Horn Cells - physiology</subject><subject>Prefrontal Cortex - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reaction Time - physiology</subject><subject>Touch - physiology</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEokvhFVDEgVsWj53YCQcktJR20bJF0J4tx5lsXCXx1k521SfgtevsriicOM1o_M83v_VH0Tsgc8go-3DX4-is12ZOISE8IRSyYk4JgWfRLCiKhKYEnkczQgVJeCrSs-iV93eEEEFAvIzOAGiaCUJm0e8fyqnSKd0Y1cbLfkDXh2alQhPqerrU-3hh-x0-xGurjcbtYHYYf0fv1QZ9XDvbxUOD8RfEbdjsTK98bOvjzDofOFfW9fFgD6NwJKAPMhffNFM7-tfRi1q1Ht-c6nl0-_XiZnGVrK4vl4vPq0RzIoZEs5zpjAFAXpWM0bwUWpRVQVmFSjPM07IusRZMlHUGZYkF1qyocgKIqQbBzqNPR-52LDusNB7MyK0znXIP0ioj_33pTSM3die54JQDBMD7E8DZ-xH9IDvjNbat6tGOXgpe8LQo-H-FkIPIC0aD8ONRqEOo3mH9xw0QOQUuv60vbn9e_1osJQVJuDwELqfAw_Lbv__ztHpK-MlGYzbN3jiUvlNtG-Qg9_t9AHI54dgjsJi6eQ</recordid><startdate>20010315</startdate><enddate>20010315</enddate><creator>Bourgeais, Laurence</creator><creator>Monconduit, Lenaic</creator><creator>Villanueva, Luis</creator><creator>Bernard, Jean-Francois</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010315</creationdate><title>Parabrachial Internal Lateral Neurons Convey Nociceptive Messages from the Deep Laminas of the Dorsal Horn to the Intralaminar Thalamus</title><author>Bourgeais, Laurence ; Monconduit, Lenaic ; Villanueva, Luis ; Bernard, Jean-Francois</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-c383c531118db3328b7c7bd923deac3e84bfbef737bf51bbe9ef39d801ee4c173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Afferent Pathways - cytology</topic><topic>Afferent Pathways - drug effects</topic><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Electric Stimulation</topic><topic>Evoked Potentials - physiology</topic><topic>Intralaminar Thalamic Nuclei - cytology</topic><topic>Intralaminar Thalamic Nuclei - physiology</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - pharmacology</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Physical Stimulation</topic><topic>Posterior Horn Cells - cytology</topic><topic>Posterior Horn Cells - drug effects</topic><topic>Posterior Horn Cells - physiology</topic><topic>Prefrontal Cortex - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reaction Time - physiology</topic><topic>Touch - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bourgeais, Laurence</creatorcontrib><creatorcontrib>Monconduit, Lenaic</creatorcontrib><creatorcontrib>Villanueva, Luis</creatorcontrib><creatorcontrib>Bernard, Jean-Francois</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bourgeais, Laurence</au><au>Monconduit, Lenaic</au><au>Villanueva, Luis</au><au>Bernard, Jean-Francois</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parabrachial Internal Lateral Neurons Convey Nociceptive Messages from the Deep Laminas of the Dorsal Horn to the Intralaminar Thalamus</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2001-03-15</date><risdate>2001</risdate><volume>21</volume><issue>6</issue><spage>2159</spage><epage>2165</epage><pages>2159-2165</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>This study investigates the physiological properties of parabrachial internal lateral (PBil) neurons that project to the paracentral thalamic (PC) nucleus using antidromic activation and single-unit recording techniques in anesthetized rat. We reported here that most of these neurons responded exclusively to the nociceptive stimulation of large receptive fields with a sustained firing that often outlasted the stimulus up to several minutes. These responses were depressed by intravenous morphine. Our results demonstrated a novel spino-PBil-PC pathway, which transmits nociceptive messages to the PC nucleus, which in turn projects to the prefrontal cortex. Recent clinical imaging studies showed the important participation of prefrontal cortex in emotional response to pain. This spino-PBil-PC pathway may explain how nociceptive messages reach the prefrontal cortex and thus trigger unbearable aversive aspects of pain.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>11245700</pmid><doi>10.1523/jneurosci.21-06-02159.2001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Afferent Pathways - cytology Afferent Pathways - drug effects Afferent Pathways - physiology Animals Electric Stimulation Evoked Potentials - physiology Intralaminar Thalamic Nuclei - cytology Intralaminar Thalamic Nuclei - physiology Male Morphine - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Pain Pain Measurement Physical Stimulation Posterior Horn Cells - cytology Posterior Horn Cells - drug effects Posterior Horn Cells - physiology Prefrontal Cortex - physiology Rats Rats, Sprague-Dawley Reaction Time - physiology Touch - physiology |
| title | Parabrachial Internal Lateral Neurons Convey Nociceptive Messages from the Deep Laminas of the Dorsal Horn to the Intralaminar Thalamus |
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