Excitatory Nicotinic and Desensitizing Muscarinic (M2) Effects on C-Nociceptors in Isolated Rat Skin

The actions of different cholinergic agonists and antagonists were investigated on nociceptive afferents using the rat skin-saphenous nerve preparation, in vitro. Nicotine was able to weakly excite C-nociceptors and to induce a mild sensitization to heat stimulation (in 77% of tested fibers) in a do...

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Veröffentlicht in:	The Journal of neuroscience 2001-05, Vol.21 (9), p.3295-3302
Hauptverfasser:	Bernardini, Nadia, Sauer, Susanne K, Haberberger, Rainer, Fischer, Michael J. M, Reeh, Peter W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Acetylcholine - physiology Animals Cholinergic Agonists - pharmacology Cholinergic Antagonists - pharmacology Dose-Response Relationship, Drug Electric Stimulation Hot Temperature Immunohistochemistry In Vitro Techniques Male Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Nerve Fibers - drug effects Nerve Fibers - metabolism Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Nociceptors - cytology Nociceptors - drug effects Nociceptors - metabolism Pain Measurement - drug effects Pain Threshold - drug effects Pain Threshold - physiology Physical Stimulation Rats Rats, Wistar Receptor, Muscarinic M2 Receptors, Muscarinic - metabolism Receptors, Nicotinic - metabolism Sensory Thresholds - drug effects Sensory Thresholds - physiology Skin - cytology Skin - innervation
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