Multiple Distinct Signal Pathways, Including an Autocrine Neurotrophic Mechanism, Contribute to the Survival-Promoting Effect of Depolarization on Spiral Ganglion Neurons In Vitro

We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP) (a permeant cAMP analog), and membrane depolarization promote spiral ganglion neuron (SGN) survival in vitro in an additive manner, depolarization having the greatest efficacy. Expression of both BDNF and of N...

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Veröffentlicht in:	The Journal of neuroscience 2001-04, Vol.21 (7), p.2256-2267
Hauptverfasser:	Hansen, Marlan R, Zha, Xiang-Ming, Bok, Jinwoong, Green, Steven H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Communication - physiology Cell Survival - physiology Cells, Cultured Cyclic AMP - physiology Membrane Potentials - physiology Rats Signal Transduction - physiology spiral ganglion Spiral Ganglion - physiology
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