Repeated Cocaine Administration Attenuates Group I Metabotropic Glutamate Receptor-Mediated Glutamate Release and Behavioral Activation: A Potential Role for Homer

The present study aimed to characterize a functional role for group I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens and the capacity of repeated cocaine to elicit long-term changes in group I mGluR function. Reverse dialysis of the group I agonist (RS)-3,5-dihydroxyphenylglycine...

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Veröffentlicht in:	The Journal of neuroscience 2001-11, Vol.21 (22), p.9043-9052
Hauptverfasser:	Swanson, Chad J, Baker, David A, Carson, Dan, Worley, Paul F, Kalivas, Peter W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Chemistry - drug effects Calcium Channel Blockers - pharmacology Carrier Proteins - metabolism Cocaine - administration & dosage Drug Administration Schedule Drug Tolerance Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Extracellular Space - chemistry Extracellular Space - metabolism Glutamic Acid - metabolism Glycine - analogs & derivatives Glycine - pharmacology Homer Scaffolding Proteins Male Microdialysis Motor Activity - drug effects Neuropeptides - metabolism Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Rats Rats, Inbred Strains Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, AMPA - metabolism Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Resorcinols - pharmacology Tetrodotoxin - administration & dosage
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