Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans

Central nervous system tuberculosis (TB) is devastating and affects vulnerable populations. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculous meningitis (TBM) specifically are nearly uniformly fatal, with little information being available to guide the treatment of these pat...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-10, Vol.63 (10)
Hauptverfasser:	Tucker, Elizabeth W, Pieterse, Lisa, Zimmerman, Matthew D, Udwadia, Zarir F, Peloquin, Charles A, Gler, Maria Tarcela, Ganatra, Shashank, Tornheim, Jeffrey A, Chawla, Prerna, Caoili, Janice C, Ritchie, Brittaney, Jain, Sanjay K, Dartois, Véronique, Dooley, Kelly E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Central Nervous System Central Nervous System - metabolism Experimental Therapeutics Female Humans Male Mycobacterium tuberculosis - drug effects Nitroimidazoles Nitroimidazoles - pharmacokinetics Oxazoles Oxazoles - pharmacokinetics Rabbits Treatment Outcome Tuberculosis, Meningeal Tuberculosis, Meningeal - drug therapy Tuberculosis, Meningeal - metabolism Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - metabolism
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