Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes

Osteocytes are terminally differentiated osteoblasts embedded in the bone matrix. Evidence indicates that cells in the mesenchymal lineage possess plasticity. However, whether or not osteocytes have the capacity to dedifferentiate back into osteoblasts is unclear. This study aimed to clarify the ded...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2019-09, Vol.9 (1), p.13842-9, Article 13842
Hauptverfasser:	Sawa, Naruhiko, Fujimoto, Hiroki, Sawa, Yoshihiko, Yamashita, Junro
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/34 14/63 631/45 631/80 Adaptor Proteins, Signal Transducing - metabolism Alkaline Phosphatase - metabolism Animals Biomarkers - metabolism Bone matrix Cell Culture Techniques - methods Cell cycle Cell Dedifferentiation Cell Differentiation Cell Proliferation Cells, Cultured Collagen Cytoplasm Extracellular Matrix Proteins - metabolism Fibroblast Growth Factor-23 Fibroblast Growth Factors - metabolism Fibroblasts Gene Expression Regulation Gene manipulation Humanities and Social Sciences Mesenchyme Mice Mineralization multidisciplinary Nodules Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteocytes Osteocytes - cytology Osteocytes - metabolism Science Science (multidisciplinary) Skull - cytology SOST protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!