CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

Age Related Macular Degeneration (AMD) is the first cause of social blindness in people aged over 65 leading to atrophy of retinal pigment epithelial cells (RPE), photoreceptors and choroids, eventually associated with choroidal neovascularization. Accumulation of undigested cellular debris within R...

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Veröffentlicht in:	Scientific reports 2019-09, Vol.9 (1), p.13873-12, Article 13873
Hauptverfasser:	Borras, Céline, Canonica, Jérémie, Jorieux, Sylvie, Abache, Toufik, El Sanharawi, Mohamed, Klein, Christophe, Delaunay, Kimberley, Jonet, Laurent, Salvodelli, Michèle, Naud, Marie-Christine, Arsenijevic, Yvan, Shalabi, Andrée, Souchaud, Landry, Behar-Cohen, Francine, Dinet, Virginie
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 14 14/19 14/28 38 631/250/2501 631/378/2613 Aldehydes - pharmacology Apoptosis Apoptosis - drug effects Atrophy Blindness Blotting, Western Caspase Caspases - metabolism Cell culture Cell death Cell Death - drug effects Cell Line Cell survival Complement factor H Complement Factor H - pharmacology Complement Membrane Attack Complex - drug effects Complement Membrane Attack Complex - metabolism Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Inflammation Life Sciences Lipids Macular degeneration Membrane attack complex Microscopy, Electron, Transmission Mortality multidisciplinary Oxidative stress Oxidative Stress - drug effects Oxidizing agents Phospholipids Photoreception Photoreceptors Pluripotency Real-Time Polymerase Chain Reaction Recombinant Proteins Retina Retinal pigment epithelium Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Science Science (multidisciplinary) Stem cells Tight junctions Tight Junctions - drug effects Vascularization
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