The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)
Background The aim of this study was to evaluate the direct effects of matrix metalloproteinase ( MMP9 rs17577, MMP9 rs17576) and alfa 2 adrenergic receptor ( ADRA2A rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 2019-05, Vol.85 (6), p.822-829 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 829 |
|---|---|
| container_issue | 6 |
| container_start_page | 822 |
| container_title | Pediatric research |
| container_volume | 85 |
| creator | Mărginean, Cristina Oana Mărginean, Claudiu Bănescu, Claudia Meliţ, Lorena Elena Tripon, Florin Iancu, Mihaela |
| description | Background
The aim of this study was to evaluate the direct effects of matrix metalloproteinase (
MMP9
rs17577,
MMP9
rs17576) and alfa 2 adrenergic receptor (
ADRA2A
rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn’s birth weight (BW), taking into account the presence of other related factors.
Methods
We performed a cross-sectional study in 197 mother–newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.
Results
BW was positively correlated with maternal age (
p
= 0.021) and the educational level (
p
= 0.002), and negatively correlated with smoking status in pregnant women (
p
|
| doi_str_mv | 10.1038/s41390-019-0347-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6760549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2185566856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-8f7d4dfa0419efdda4b8b07f2ba61cf92880654b323de033978b85fcf3e321653</originalsourceid><addsrcrecordid>eNp1kctu1DAYhS0EotPCA7BBlti0i4BvSRwWSEMpF6lVURnWlpP8maRy7GA7lNnxDqzY8HA8CR6mlIvEypbPd85v-yD0gJLHlHD5JAjKK5IRWmWEizJjt9CC5jydCFHeRgtCOM14Vck9tB_CJSFU5FLcRXuclBUlgi_Qt1UP2IPRcXA29MOEa4hXABafnb2tsLYtXr64WLIlXoMFPDmzGZ2f-iGM4ac6utiDD98_f7FwVTtv0_YrtnP0wzZSGxyijnN4mmgMnybjvI7Ob_CkY5_cLRh8-G51cf78BDdunMygbcTax6ExcHQP3em0CXD_ej1A71-erI5fZ6fnr94cL0-zRpQkZrIrW9F2mghaQde2WtSyJmXHal3QpquYlKTIRc0Zb4FwXpWylnnXdBw4o0XOD9CzXe401yO0DdjotVGTH0btN8rpQf2t2KFXa_dRFWVBclGlgMPrAO8-zBCiGofQgDHagpuDYlTmeVHIvEjoo3_QSzf79FOJYrQUxba9RNEd1XgXgofu5jKUqG37ate-Su2rbfuKJc_DP19x4_hVdwLYDghJsmvwv0f_P_UH1Fe_QA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2217460447</pqid></control><display><type>article</type><title>The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Mărginean, Cristina Oana ; Mărginean, Claudiu ; Bănescu, Claudia ; Meliţ, Lorena Elena ; Tripon, Florin ; Iancu, Mihaela</creator><creatorcontrib>Mărginean, Cristina Oana ; Mărginean, Claudiu ; Bănescu, Claudia ; Meliţ, Lorena Elena ; Tripon, Florin ; Iancu, Mihaela</creatorcontrib><description>Background
The aim of this study was to evaluate the direct effects of matrix metalloproteinase (
MMP9
rs17577,
MMP9
rs17576) and alfa 2 adrenergic receptor (
ADRA2A
rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn’s birth weight (BW), taking into account the presence of other related factors.
Methods
We performed a cross-sectional study in 197 mother–newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.
Results
BW was positively correlated with maternal age (
p
= 0.021) and the educational level (
p
= 0.002), and negatively correlated with smoking status in pregnant women (
p
< 0.001). The
MMP9
rs17577 variant genotypes in mothers led to a lower BW (
p
= 0.049). The mothers with a variant genotype of
ADRA2A
rs553668 gene polymorphism had newborns with a higher BW (
p
= 0.030). MWG and gestational age (GesAge) influenced BW (
p
< 0.05). We noticed that newborns’ variant genotype of
MMP9
rs17577 was related to a significant increase in BW (
p
= 0.010), while the newborns who carried the variant genotype of
MMP9
rs17576 expressed a negative correlation, decreasing the BW (
p
= 0.032).
Conclusion
Our study emphasizes the role of
MMP9
rs17577,
MMP9
rs17576, and
ADRA2A
rs553668 SNPs in BW determinism.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-019-0347-2</identifier><identifier>PMID: 30791043</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Birth Weight - genetics ; Clinical ; Clinical Research Article ; Cross-Sectional Studies ; Female ; Genotype & phenotype ; Gestational Weight Gain - genetics ; Humans ; Infant Nutritional Physiological Phenomena - genetics ; Infant, Newborn ; Male ; Maternal Nutritional Physiological Phenomena - genetics ; Maternal-Fetal Exchange - genetics ; Matrix Metalloproteinase 9 - genetics ; Medicine ; Medicine & Public Health ; Models, Genetic ; Mothers ; Nutritional Status - genetics ; Pediatric Surgery ; Pediatrics ; Physical growth ; Polymorphism ; Polymorphism, Single Nucleotide ; Pregnancy ; Receptors, Adrenergic, alpha-2 - genetics ; Romania ; Young Adult</subject><ispartof>Pediatric research, 2019-05, Vol.85 (6), p.822-829</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-8f7d4dfa0419efdda4b8b07f2ba61cf92880654b323de033978b85fcf3e321653</citedby><cites>FETCH-LOGICAL-c470t-8f7d4dfa0419efdda4b8b07f2ba61cf92880654b323de033978b85fcf3e321653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30791043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mărginean, Cristina Oana</creatorcontrib><creatorcontrib>Mărginean, Claudiu</creatorcontrib><creatorcontrib>Bănescu, Claudia</creatorcontrib><creatorcontrib>Meliţ, Lorena Elena</creatorcontrib><creatorcontrib>Tripon, Florin</creatorcontrib><creatorcontrib>Iancu, Mihaela</creatorcontrib><title>The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
The aim of this study was to evaluate the direct effects of matrix metalloproteinase (
MMP9
rs17577,
MMP9
rs17576) and alfa 2 adrenergic receptor (
ADRA2A
rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn’s birth weight (BW), taking into account the presence of other related factors.
Methods
We performed a cross-sectional study in 197 mother–newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.
Results
BW was positively correlated with maternal age (
p
= 0.021) and the educational level (
p
= 0.002), and negatively correlated with smoking status in pregnant women (
p
< 0.001). The
MMP9
rs17577 variant genotypes in mothers led to a lower BW (
p
= 0.049). The mothers with a variant genotype of
ADRA2A
rs553668 gene polymorphism had newborns with a higher BW (
p
= 0.030). MWG and gestational age (GesAge) influenced BW (
p
< 0.05). We noticed that newborns’ variant genotype of
MMP9
rs17577 was related to a significant increase in BW (
p
= 0.010), while the newborns who carried the variant genotype of
MMP9
rs17576 expressed a negative correlation, decreasing the BW (
p
= 0.032).
Conclusion
Our study emphasizes the role of
MMP9
rs17577,
MMP9
rs17576, and
ADRA2A
rs553668 SNPs in BW determinism.</description><subject>Adult</subject><subject>Birth Weight - genetics</subject><subject>Clinical</subject><subject>Clinical Research Article</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Gestational Weight Gain - genetics</subject><subject>Humans</subject><subject>Infant Nutritional Physiological Phenomena - genetics</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Maternal Nutritional Physiological Phenomena - genetics</subject><subject>Maternal-Fetal Exchange - genetics</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Genetic</subject><subject>Mothers</subject><subject>Nutritional Status - genetics</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Physical growth</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Receptors, Adrenergic, alpha-2 - genetics</subject><subject>Romania</subject><subject>Young Adult</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctu1DAYhS0EotPCA7BBlti0i4BvSRwWSEMpF6lVURnWlpP8maRy7GA7lNnxDqzY8HA8CR6mlIvEypbPd85v-yD0gJLHlHD5JAjKK5IRWmWEizJjt9CC5jydCFHeRgtCOM14Vck9tB_CJSFU5FLcRXuclBUlgi_Qt1UP2IPRcXA29MOEa4hXABafnb2tsLYtXr64WLIlXoMFPDmzGZ2f-iGM4ac6utiDD98_f7FwVTtv0_YrtnP0wzZSGxyijnN4mmgMnybjvI7Ob_CkY5_cLRh8-G51cf78BDdunMygbcTax6ExcHQP3em0CXD_ej1A71-erI5fZ6fnr94cL0-zRpQkZrIrW9F2mghaQde2WtSyJmXHal3QpquYlKTIRc0Zb4FwXpWylnnXdBw4o0XOD9CzXe401yO0DdjotVGTH0btN8rpQf2t2KFXa_dRFWVBclGlgMPrAO8-zBCiGofQgDHagpuDYlTmeVHIvEjoo3_QSzf79FOJYrQUxba9RNEd1XgXgofu5jKUqG37ate-Su2rbfuKJc_DP19x4_hVdwLYDghJsmvwv0f_P_UH1Fe_QA</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Mărginean, Cristina Oana</creator><creator>Mărginean, Claudiu</creator><creator>Bănescu, Claudia</creator><creator>Meliţ, Lorena Elena</creator><creator>Tripon, Florin</creator><creator>Iancu, Mihaela</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190501</creationdate><title>The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)</title><author>Mărginean, Cristina Oana ; Mărginean, Claudiu ; Bănescu, Claudia ; Meliţ, Lorena Elena ; Tripon, Florin ; Iancu, Mihaela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-8f7d4dfa0419efdda4b8b07f2ba61cf92880654b323de033978b85fcf3e321653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Birth Weight - genetics</topic><topic>Clinical</topic><topic>Clinical Research Article</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Genotype & phenotype</topic><topic>Gestational Weight Gain - genetics</topic><topic>Humans</topic><topic>Infant Nutritional Physiological Phenomena - genetics</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Maternal Nutritional Physiological Phenomena - genetics</topic><topic>Maternal-Fetal Exchange - genetics</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Genetic</topic><topic>Mothers</topic><topic>Nutritional Status - genetics</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Physical growth</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Receptors, Adrenergic, alpha-2 - genetics</topic><topic>Romania</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mărginean, Cristina Oana</creatorcontrib><creatorcontrib>Mărginean, Claudiu</creatorcontrib><creatorcontrib>Bănescu, Claudia</creatorcontrib><creatorcontrib>Meliţ, Lorena Elena</creatorcontrib><creatorcontrib>Tripon, Florin</creatorcontrib><creatorcontrib>Iancu, Mihaela</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mărginean, Cristina Oana</au><au>Mărginean, Claudiu</au><au>Bănescu, Claudia</au><au>Meliţ, Lorena Elena</au><au>Tripon, Florin</au><au>Iancu, Mihaela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>85</volume><issue>6</issue><spage>822</spage><epage>829</epage><pages>822-829</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
The aim of this study was to evaluate the direct effects of matrix metalloproteinase (
MMP9
rs17577,
MMP9
rs17576) and alfa 2 adrenergic receptor (
ADRA2A
rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn’s birth weight (BW), taking into account the presence of other related factors.
Methods
We performed a cross-sectional study in 197 mother–newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.
Results
BW was positively correlated with maternal age (
p
= 0.021) and the educational level (
p
= 0.002), and negatively correlated with smoking status in pregnant women (
p
< 0.001). The
MMP9
rs17577 variant genotypes in mothers led to a lower BW (
p
= 0.049). The mothers with a variant genotype of
ADRA2A
rs553668 gene polymorphism had newborns with a higher BW (
p
= 0.030). MWG and gestational age (GesAge) influenced BW (
p
< 0.05). We noticed that newborns’ variant genotype of
MMP9
rs17577 was related to a significant increase in BW (
p
= 0.010), while the newborns who carried the variant genotype of
MMP9
rs17576 expressed a negative correlation, decreasing the BW (
p
= 0.032).
Conclusion
Our study emphasizes the role of
MMP9
rs17577,
MMP9
rs17576, and
ADRA2A
rs553668 SNPs in BW determinism.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>30791043</pmid><doi>10.1038/s41390-019-0347-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2019-05, Vol.85 (6), p.822-829 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6760549 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Birth Weight - genetics Clinical Clinical Research Article Cross-Sectional Studies Female Genotype & phenotype Gestational Weight Gain - genetics Humans Infant Nutritional Physiological Phenomena - genetics Infant, Newborn Male Maternal Nutritional Physiological Phenomena - genetics Maternal-Fetal Exchange - genetics Matrix Metalloproteinase 9 - genetics Medicine Medicine & Public Health Models, Genetic Mothers Nutritional Status - genetics Pediatric Surgery Pediatrics Physical growth Polymorphism Polymorphism, Single Nucleotide Pregnancy Receptors, Adrenergic, alpha-2 - genetics Romania Young Adult |
| title | The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T15%3A16%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relationship%20between%20MMP9%20and%20ADRA2A%20gene%20polymorphisms%20and%20mothers%E2%80%93newborns%E2%80%99%20nutritional%20status:%20an%20exploratory%20path%20model%20(STROBE%20compliant%20article)&rft.jtitle=Pediatric%20research&rft.au=M%C4%83rginean,%20Cristina%20Oana&rft.date=2019-05-01&rft.volume=85&rft.issue=6&rft.spage=822&rft.epage=829&rft.pages=822-829&rft.issn=0031-3998&rft.eissn=1530-0447&rft_id=info:doi/10.1038/s41390-019-0347-2&rft_dat=%3Cproquest_pubme%3E2185566856%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2217460447&rft_id=info:pmid/30791043&rfr_iscdi=true |