Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

Inhibition of Carbonic Anhydrases (CAs) has been clinically exploited for many decades for a variety of therapeutic applications. Within a research project aimed at developing novel classes of CA inhibitors (CAIs) with a proper selectivity for certain isoforms, a series of derivatives featuring the...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2019-01, Vol.34 (1), p.1697-1710
Hauptverfasser:	Milite, Ciro, Amendola, Giorgio, Nocentini, Alessio, Bua, Silvia, Cipriano, Alessandra, Barresi, Elisabetta, Feoli, Alessandra, Novellino, Ettore, Da Settimo, Federico, Supuran, Claudiu T., Castellano, Sabrina, Cosconati, Sandro, Taliani, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry benzimidazole-sulfonamides Benzimidazoles - chemistry Carbonic Anhydrase I - antagonists & inhibitors Carbonic Anhydrase II - antagonists & inhibitors Carbonic anhydrase inhibitors Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - chemistry Humans Isoenzymes - metabolism isoform-selective inhibitors molecular docking Molecular Docking Simulation Molecular Structure Nerve Tissue Proteins - antagonists & inhibitors reduced flexibility approach Research Paper Schiff Bases - chemistry Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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