Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors

Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism. To assess the effects of dopamine on photoreceptor physiology, we examined the morphology, electrophysiology, and regu...

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Veröffentlicht in:	The Journal of neuroscience 2002-03, Vol.22 (6), p.2063-2073
Hauptverfasser:	Nir, Izhak, Harrison, Joseph M, Haque, Rashidul, Low, Malcolm J, Grandy, David K, Rubinstein, Marcelo, Iuvone, P. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Ocular - physiology Animals Cell Survival - genetics Cyclic AMP - metabolism Darkness Dopamine - metabolism Dopamine Agonists - pharmacology Glutamic Acid - metabolism In Vitro Techniques Light Mice Mice, Inbred C57BL Mice, Knockout Phagocytosis - physiology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Photoreceptor Cells, Vertebrate - radiation effects Quinpirole - pharmacology Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - deficiency Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 Retina - drug effects Retina - metabolism Retina - radiation effects Rod Cell Outer Segment - ultrastructure
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