Insulin and Fibroblast Growth Factor 2 Activate a Neurogenic Program in Muller Glia of the Chicken Retina

We have reported previously that neurotoxic damage to the chicken retina causes Müller glia to dedifferentiate, proliferate, express transcription factors common to retinal progenitors, and generate new neurons and glia, whereas the majority of newly produced cells remain undifferentiated (Fischer a...

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Veröffentlicht in:	The Journal of neuroscience 2002-11, Vol.22 (21), p.9387-9398
Hauptverfasser:	Fischer, Andy J, McGuire, Christopher Roger, Dierks, Blair Dorian, Reh, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Proteins Cell Cycle - drug effects Cell Differentiation - drug effects Cell Division - drug effects Chickens Drug Administration Routes Drug Synergism Eye Proteins - biosynthesis Fibroblast Growth Factor 2 - pharmacology Glutamate-Ammonia Ligase - antagonists & inhibitors Glutamate-Ammonia Ligase - metabolism Homeodomain Proteins - biosynthesis Insulin - pharmacology Neuroglia - cytology Neuroglia - drug effects Neurons - cytology Neurons - drug effects Paired Box Transcription Factors PAX6 Transcription Factor Regeneration - drug effects Repressor Proteins Retina - cytology Retina - drug effects Retina - growth & development Stem Cells - cytology Stem Cells - drug effects Transcription Factors - biosynthesis
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