Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia

In addition to its role as a CNS neurotransmitter, glutamate has been shown recently to be an important component of the peripheral inflammation response. We demonstrated previously that the group I metabotropic glutamate receptors (mGluRs) mGlu1 and mGlu5 are expressed in the peripheral terminals o...

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Veröffentlicht in:	The Journal of neuroscience 2002-09, Vol.22 (17), p.7444-7452
Hauptverfasser:	Hu, Hui-Juan, Bhave, Gautam, Gereau, Robert W., IV
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Capsaicin Cells, Cultured Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Diglycerides - metabolism Dinoprostone - pharmacology Enzyme Inhibitors - pharmacology Excitatory Amino Acid Agonists - pharmacology Hyperalgesia - chemically induced Hyperalgesia - physiopathology In Vitro Techniques Mice Mice, Inbred C57BL Neurons, Afferent - drug effects Neurons, Afferent - metabolism Pain Measurement - drug effects Patch-Clamp Techniques Phospholipids - metabolism Prostaglandins - metabolism Prostaglandins - pharmacology Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Receptor, Metabotropic Glutamate 5 Receptors, Drug - metabolism Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - metabolism Signal Transduction - drug effects Signal Transduction - physiology Type C Phospholipases - metabolism
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