D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Results from a Switch in the Regulation of ERK1/2/MAP Kinase

Dopamine effects in the striatum are mediated principally through the D1 and D2 dopamine receptor subtypes, which are segregated to the direct and indirect striatal projection neurons. After degeneration of the nigrostriatal dopamine system, direct pathway neurons display a supersensitive response t...

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Veröffentlicht in:	The Journal of neuroscience 2002-06, Vol.22 (12), p.5042-5054
Hauptverfasser:	Gerfen, Charles R, Miyachi, Shigehiro, Paletzki, Ronald, Brown, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - enzymology Afferent Pathways - metabolism Animals Corpus Striatum - enzymology Corpus Striatum - metabolism Denervation Dopamine - metabolism Enzyme Inhibitors - pharmacology Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics Male Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Models, Neurological Neurons - enzymology Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - metabolism RNA, Messenger - biosynthesis Signal Transduction Substantia Nigra - physiology Transcriptional Activation
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