12-Hydroxyeicosatetrenoate (12-HETE) Attenuates AMPA Receptor-Mediated Neurotoxicity: Evidence for a G-Protein-Coupled HETE Receptor

12-hydroxyeicosatetraenoic acid (12-HETE) is a neuromodulator that is synthesized during ischemia. Its neuronal effects include attenuation of calcium influx and glutamate release as well as inhibition of AMPA receptor (AMPA-R) activation. Because 12-HETE reduces ischemic injury in the heart, we exa...

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Veröffentlicht in:	The Journal of neuroscience 2002-01, Vol.22 (1), p.257-264
Hauptverfasser:	Hampson, Aidan J, Grimaldi, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid - pharmacology Adenylate Cyclase Toxin Adenylyl Cyclase Inhibitors Animals Benzothiadiazines - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Cells, Cultured Chelating Agents - pharmacology Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Glutamic Acid - toxicity GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism L-Lactate Dehydrogenase - metabolism Models, Biological Neurons - cytology Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Pertussis Toxin Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Rats Rats, Wistar Receptors, AMPA - metabolism Receptors, Eicosanoid - metabolism Receptors, Kainic Acid - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Virulence Factors, Bordetella - pharmacology
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