Regulation of GluR1 by the A-Kinase Anchoring Protein 79 (AKAP79) Signaling Complex Shares Properties with Long-Term Depression

Second messengers regulate synaptic plasticity by influencing the balance between kinase and phosphatase activity. One target of this balance is the phosphorylation state of the AMPA receptor glutamate receptor 1 (GluR1) subunit. Hippocampal long-term depression (LTD) is a calcium-dependent downregu...

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Veröffentlicht in:	The Journal of neuroscience 2002-04, Vol.22 (8), p.3044-3051
Hauptverfasser:	Tavalin, Steven J, Colledge, Marcie, Hell, Johannes W, Langeberg, Lorene K, Huganir, Richard L, Scott, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins Adaptor Proteins, Signal Transducing Animals Binding Sites - physiology Calcineurin - metabolism Calcium - metabolism Carrier Proteins - metabolism Cells, Cultured Cyclic AMP-Dependent Protein Kinases - metabolism Glutamic Acid - pharmacology Kidney - cytology Kidney - metabolism Macromolecular Substances Membrane Proteins Nerve Tissue Proteins - metabolism Neural Inhibition - physiology Neuronal Plasticity - physiology Neurons - cytology Neurons - metabolism Patch-Clamp Techniques Phosphorylation Precipitin Tests Protein Binding Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Second Messenger Systems - physiology Signal Transduction - physiology Time
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