Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells

The NF-κB pathway has been reported to play a very important role in the process of intervertebral disc degeneration (IVDD). Our results demonstrated that knockdown of NF-κB with P65-siRNA can significantly decrease cell apoptosis and the expression of pro-inflammation factors TNF-α and IL-1β in LPS...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2019-09, Vol.11 (17), p.7294-7306
Hauptverfasser:	Yi, Weiwei, Wen, Yafeng, Tan, Fuqiang, Liu, Xi, Lan, Haiyang, Ye, He, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Case-Control Studies Cells, Cultured Humans Inflammation - metabolism Intervertebral Disc Degeneration - metabolism NF-kappa B - metabolism Nucleus Pulposus - metabolism Research Paper
Online-Zugang:	Volltext
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