Red meat consumption, risk of incidence of cardiovascular disease and cardiovascular mortality, and the dose–response effect: Protocol for a systematic review and meta-analysis of longitudinal cohort studies

Red and (particularly) processed meats are high in cholesterol and saturated and solid fatty acids. Their consumption is considered one of the risk factors for metabolic disorders. Numerous studies demonstrated a possible association between red meat consumption and cardiovascular disease (CVD). In...

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Veröffentlicht in:Medicine (Baltimore) 2019-09, Vol.98 (38), p.e17271-e17271
Hauptverfasser: Medeiros, Gidyenne Christine Bandeira Silva de, Azevedo, Kesley Pablo Morais de, Mesquita, Gabriella Xavier Barbalho, Lima, Severina Carla Vieira Cunha, Silva, David Franciole de Oliveira, Pimenta, Isac Davidson Santiago Fernandes, Gonçalves, Ana Katherine da Silveira, Lyra, Clélia de Oliveira, Piuvezam, Grasiela
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container_issue 38
container_start_page e17271
container_title Medicine (Baltimore)
container_volume 98
creator Medeiros, Gidyenne Christine Bandeira Silva de
Azevedo, Kesley Pablo Morais de
Mesquita, Gabriella Xavier Barbalho
Lima, Severina Carla Vieira Cunha
Silva, David Franciole de Oliveira
Pimenta, Isac Davidson Santiago Fernandes
Gonçalves, Ana Katherine da Silveira
Lyra, Clélia de Oliveira
Piuvezam, Grasiela
description Red and (particularly) processed meats are high in cholesterol and saturated and solid fatty acids. Their consumption is considered one of the risk factors for metabolic disorders. Numerous studies demonstrated a possible association between red meat consumption and cardiovascular disease (CVD). In this protocol, we propose a systematic review of the literature to examine the associations of red meat consumption with CVD incidence and mortality, and explore the potential dose-response relationship. We will search MEDLINE/PubMed, Scopus, SciELO, LILACS, ScienceDirect, Web of Science, Cochrane (CENTRAL), WHOLIS, PAHO, and Embase. We will include prospective epidemiological studies (longitudinal cohort). Risk of bias will be assessed using the Newcastle-Ottawa scale (NOS). Four independent researchers will conduct all evaluations. Disagreements will be referred to a fifth reviewer. We will summarize our findings using a narrative approach and tables to describe the characteristics of the included studies. The heterogeneity between trial results will be evaluated using a standard chi-squared test with P 
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Their consumption is considered one of the risk factors for metabolic disorders. Numerous studies demonstrated a possible association between red meat consumption and cardiovascular disease (CVD). In this protocol, we propose a systematic review of the literature to examine the associations of red meat consumption with CVD incidence and mortality, and explore the potential dose-response relationship. We will search MEDLINE/PubMed, Scopus, SciELO, LILACS, ScienceDirect, Web of Science, Cochrane (CENTRAL), WHOLIS, PAHO, and Embase. We will include prospective epidemiological studies (longitudinal cohort). Risk of bias will be assessed using the Newcastle-Ottawa scale (NOS). Four independent researchers will conduct all evaluations. Disagreements will be referred to a fifth reviewer. We will summarize our findings using a narrative approach and tables to describe the characteristics of the included studies. The heterogeneity between trial results will be evaluated using a standard chi-squared test with P &lt; .05. We will conduct the study in accordance with the guideline of the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA-P). This review will evaluate the association between red meat consumption and incidence of CVD and mortality (primary outcome measures). The secondary outcome measure will include the dose-response effect. The findings of this systematic review will summarize the latest evidence of the association between red meat consumption and incidence of CVD and mortality and the dose-response effect through a systematic review and meta-analysis. PROSPERO CRD42019100914.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000017271</identifier><identifier>PMID: 31568006</identifier><language>eng</language><publisher>United States: the Author(s). 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Their consumption is considered one of the risk factors for metabolic disorders. Numerous studies demonstrated a possible association between red meat consumption and cardiovascular disease (CVD). In this protocol, we propose a systematic review of the literature to examine the associations of red meat consumption with CVD incidence and mortality, and explore the potential dose-response relationship. We will search MEDLINE/PubMed, Scopus, SciELO, LILACS, ScienceDirect, Web of Science, Cochrane (CENTRAL), WHOLIS, PAHO, and Embase. We will include prospective epidemiological studies (longitudinal cohort). Risk of bias will be assessed using the Newcastle-Ottawa scale (NOS). Four independent researchers will conduct all evaluations. Disagreements will be referred to a fifth reviewer. We will summarize our findings using a narrative approach and tables to describe the characteristics of the included studies. 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subjects Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Diet - adverse effects
Diet - statistics & numerical data
Humans
Incidence
Longitudinal Studies
Red Meat - adverse effects
Red Meat - statistics & numerical data
Risk Factors
Study Protocol Systematic Review
title Red meat consumption, risk of incidence of cardiovascular disease and cardiovascular mortality, and the dose–response effect: Protocol for a systematic review and meta-analysis of longitudinal cohort studies
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