TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila

Organ size is regulated by intercellular signaling for cell growth and proliferation. The TOR pathway mediates a key signaling mechanism for controlling cell size and number in organ growth. Chaperonin containing TCP-1 (CCT) is a complex that assists protein folding and function, but its role in ani...

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Veröffentlicht in:	Oncogene 2019-06, Vol.38 (24), p.4739-4754
Hauptverfasser:	Kim, Ah-Ram, Choi, Kwang-Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 13/51 13/89 13/95 14/19 631/136/334 631/136/83/2359 631/208 82/29 82/80 82/83 96/109 96/2 96/34 96/63 AKT protein Analysis Animal Structures - growth & development Animal Structures - metabolism Animals Animals, Genetically Modified Apoptosis Cell Biology Cell death Cell proliferation Cell size Chaperonin Containing TCP-1 - physiology Chaperonins Chaperonins - genetics Chaperonins - physiology Drosophila Drosophila - embryology Drosophila - genetics Drosophila - growth & development Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation, Developmental Human Genetics Insects Insulin Insulin - metabolism Internal Medicine Kinases Medicine Medicine & Public Health Multiprotein Complexes - physiology Oncology Organogenesis - genetics Phenotypes Phosphorylation Protein folding RNA-mediated interference Signal transduction Signal Transduction - genetics TOR Serine-Threonine Kinases - metabolism Transcription Wings, Animal - growth & development Wings, Animal - metabolism
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